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Regular use of nonsteroidal anti-inflammatory drugs is associated with improved survival among colorectal cancer survivors with KRAS wild-type tumors

NSAID Use, Survival Link Varies With KRAS Status in CRC Patients

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Use of NSAIDs tied to better survival for colorectal cancer survivors with KRAS wild-type tumors
The physical and mental health benefits of pursuits like yoga and meditation begin in the genes

Yoga May Be Able to ‘Reverse’ Stress-Inducing DNA Reactions

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Mind-body interventions lead to decrease in nuclear factor kappa B and cytokines, researchers say
Two new medications that target specific genetic mutations may improve survival for patients with specific types of advanced non-small-cell lung cancer

ASCO: Novel Meds Show Promise in Advanced NSCLC

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Results presented from two phase III trials
An experimental study supports a TANK-binding kinase 1-dependent role for Lin28a in the hypothalamic ventromedial nucleus in glucose homeostasis. The study was published online May 26 in Diabetes.

Hypothalamic Lin28a Shows Role in Glucose Homeostasis

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Hypothalamic ventromedial Lin28a enhances glucose metabolism in diet-induced obesity in mice
Scientists have discovered another gene mutation behind certain cases of autosomal-recessive congenital ichthyosis

Mutations in SULT2B1 Tied to Ichthyosis in Humans

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Findings indicate disturbed cholesterol metabolism of skin with mutation in SULT2B1
An experimental drug that targets tropomyosin receptor kinase fusion

ASCO: Gene-Targeted Drug Shows Efficacy for Child, Adult Cancers

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Larotrectinib targets tropomyosin receptor kinase fusion proteins
The methylene tetrahydrofolate reductase (MTHFR) gene A1298C polymorphism does not appear to be related to methotrexate efficacy or toxicity in patients with rheumatoid arthritis

MTHFR A1298C Polymorphism Not Linked to MTX Outcomes in RA

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No significant link for MTHFR gene A1298C polymorphism with methotrexate efficacy, toxicity
DNA methylation testing may be feasible as a molecular triage of high-risk human papillomavirus-positive individuals for high-resolution anoscopy screening

Progress Made on Genetic Test for Anal Cancer

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But research is still in early stages
Testing for combined urinary PCA3 and TMPRSS2:ERG RNA can improve detection of prostate cancer

Combined Urine Test for T2:ERG, PCA3 Ups Prostate CA Detection

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Combined urinary testing can avoid unnecessary prostate biopsy, while preserving high sensitivity
The addition of selumetinib to docetaxel does not improve progression-free survival among patients with previously treated advanced KRAS-mutant non-small-cell lung cancer

Adding Selumetinib to Docetaxel Doesn’t Up PFS in NSCLC

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No improvement in progression-free survival for previously treated advanced KRAS-mutant NSCLC