Tag: Genetics
Insulinomas May Hold Key to Diabetes Drug Development
Novel discovery of molecular pathways may reveal map to regenerate insulin-producing cells
Clinical Exome Sequencing Useful for Critically Ill Infants
Molecular diagnosis affects medical management in ~half of infants ID'd by clinical exome sequencing
Hypermutated ctDNA Linked to Checkpoint Inhibitor Response
Patients with high alteration number in variants of unknown significance had better outcomes
CYPC19*17 Allele May Influence Response to PPI Treatment
Kids with CYPC19*17 alleles without corresponding loss-of-function alleles have longer times with pH <4
Genotype-Guided Warfarin Dosing Cuts Adverse Events
Risk of composite of major bleeding, INR ≥4, VTE, death down for hip, knee arthroplasty patients
APOE Allele Type Tied to Mortality Risk
No racial difference in the association between these alleles and mortality
Alcohol Aids Cerebellar Deficit From Movement Disorder
Cerebellar networks may play key role in symptom generation in these patients
Histamine May Play Role in Colorectal Tumorigenesis
Histamine-producing probiotic reduces inflammation, suppresses colon tumors in mice
New Link Seen Between Gene Fusion and Bladder Cancer
Previously overlooked section of fusion found to negatively impact cancer cells, researchers say
PD-L1 Mainly Expressed in Metastatic CRC Lesions
Overall, 81.8 percent of metastatic CRCs and 40.9 percent of primary lesions had PD-L1 expression
