Tag: Genetics
Concerns Surround Use of Direct-to-Consumer Genetic Testing
Issues include limited knowledge about available tests, difficulty interpreting results, lack of oversight
HER3 Linked to Improved Survival With Panitumumab
Addition of panitumumab to irinotecan tied to improved survival in RAS wt advanced colorectal CA
Smoking Alters Genetic Relationship with Parkinson’s
Smoking, HLA-DRB1 may be involved in common pathways, possibly neuroinflammation
Gene Expression Assay Classifies Diffuse Large B-Cell Lymphoma
Assay assesses expression of 21 markers, classifies most samples into expected subtype
Genetic Variant Tied to Prostate Cancer Outcomes
Time to metastasis, length of survival vary by number of HSD3B1 (1245C) variant alleles
Antisocial Behavior May Be Highly Polygenic
Promising loci that have sex-discordant associations with ASB identified
Scientists Support Genome Editing to Prevent Disease
Majority of survey respondents support gene editing to treat diseases but not human enhancement
Insulinomas May Hold Key to Diabetes Drug Development
Novel discovery of molecular pathways may reveal map to regenerate insulin-producing cells
Clinical Exome Sequencing Useful for Critically Ill Infants
Molecular diagnosis affects medical management in ~half of infants ID'd by clinical exome sequencing
Hypermutated ctDNA Linked to Checkpoint Inhibitor Response
Patients with high alteration number in variants of unknown significance had better outcomes
