Tag: Genetics
Multiple Myeloma Survival Down With High ADAR1 RNA Expression
ADAR1 knockdown reduces regeneration of high-risk multiple myeloma in patient-derived xenografts
DNA Sequencing Identifies Alpha-1 Antitrypsin Deficiency
Six rare mutations identified in seven subjects that would not have been uncovered without sequencing
ASH: New Approach to Gene Tx Restores Immune Cells in X-SCID
Efficient vector marking in bone marrow CD34+ cells, myeloid cells, B cells in newly diagnosed SCID
Gene Therapy Shows Beneficial Effect in Men With Hemophilia B
Reduction in annualized bleeding rate and in factor use with infusion of viral vector with transgene
Lipid-Linked Genetic Risk Tied to Abdominal Aortic Aneurysm
Genetic elevation of LDL-C linked to increased AAA risk; increase for HDL-C linked to lower risk of AAA
Genetic Variants Tied to Type 1 Diabetes Heterogeneity
TCF7L2 variants associated with single autoantibody, higher C-peptide, lower glucose
Researchers ID Microbiome Genes Tied to Asthma
Upper airway microbiota differs in children with asthma, asthma remission, and no asthma
LRRK2 Variants Linked to Lower Age at Onset of Parkinson’s
Participants with three risk variants of LRRK2 have significantly lower age at onset than noncarriers
PARP Inhibitors Promising Beyond BRCA1/2 Altered Tumors
Talazoparib caused regression in 5 patient-derived xenografts, 4 without germline BRCA1/2 mutations
Computed Tomography Features Vary Based on BRCA Status
Differences seen between BRCA-mutant versus BRCA wild-type high-grade serous ovarian cancer
