Tag: Genetics
Gene Therapy Shows Beneficial Effect in Men With Hemophilia B
Reduction in annualized bleeding rate and in factor use with infusion of viral vector with transgene
Lipid-Linked Genetic Risk Tied to Abdominal Aortic Aneurysm
Genetic elevation of LDL-C linked to increased AAA risk; increase for HDL-C linked to lower risk of AAA
Genetic Variants Tied to Type 1 Diabetes Heterogeneity
TCF7L2 variants associated with single autoantibody, higher C-peptide, lower glucose
Researchers ID Microbiome Genes Tied to Asthma
Upper airway microbiota differs in children with asthma, asthma remission, and no asthma
LRRK2 Variants Linked to Lower Age at Onset of Parkinson’s
Participants with three risk variants of LRRK2 have significantly lower age at onset than noncarriers
PARP Inhibitors Promising Beyond BRCA1/2 Altered Tumors
Talazoparib caused regression in 5 patient-derived xenografts, 4 without germline BRCA1/2 mutations
Computed Tomography Features Vary Based on BRCA Status
Differences seen between BRCA-mutant versus BRCA wild-type high-grade serous ovarian cancer
Internists Key to Identifying Need for Genetic Counseling for Cancer
Complexity of genetic counseling for multigene testing has increased considerably
70-Gene Signature Impacts Treatment Decisions in Breast CA
70-GS linked to change in treatment decisions for intermediate-risk patients based on 21-gene assay
Locus ID’d That Links Comorbid Alcohol Dependence, Depression
Robust association identified for SEMA3A locus in African American participants in two samples
