Tag: Genetics
MEK Inhibition Beneficial for Children With Subset of Severe Hypertrophic Cardiomyopathy
Decrease in mortality, morbidity seen with trametinib for children with RASopathy-associated hypertrophic cardiomyopathy
Candidate Genetic Variants Have Minimal Impact on Opioid Addiction Risk
Fifteen candidate genes account for only 0.40 percent of variation in opioid use disorder risk
Genomics-Informed Model Beneficial for Neurodevelopmental Disorders
Genetic diagnoses result in direct changes in management for patients with a pathogenic or likely pathogenic variant
Certain Risk Factors for MS Linked to Pediatric Brain Volume
MS-polygenic risk score and household parental smoking negatively linked to total brain volume, thalamic volume
SABCS: Risk-Reducing Surgery Improves Outcomes in Young Breast Cancer Patients With BRCA Mutations
Findings show survival benefits for both risk-reducing mastectomy and salpingo-oophorectomy
Early Bilateral Oophorectomy Increases Risk of Alzheimer Disease
Risk even higher among women with bilateral oophorectomy carrying an APOE4 allele
Model Including Polygenic Risk, Polysocial Score Improves CHD Risk Prediction
Polygenic risk score and polysocial score have independent and additive effects on coronary heart disease
Neoantigen DNA Vaccines Safe, Induce Response in Triple-Negative Breast Cancer
Fourteen of 18 patients had neoantigen-specific T-cell responses; recurrence-free survival was 87.5 percent at 36 months
Potential Genetic Link ID’d Between Thyroid Disease, Alopecia Areata
Significant genetic predictions of alopecia seen with hypothyroidism, Hashimoto thyroiditis, and subacute thyroiditis
Multigene Signature Can Help Tailor Chemo for Operable Triple-Negative Breast Cancer
Improved three-year disease-free and recurrence-free survival seen with intensive chemotherapy regimen
