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Fifteen genetic determinants of fracture

Fifteen Genetic Determinants of Fracture Identified

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All determinants also associated with bone mineral density, which showed causal effect on fracture
KLRD1-expressing natural killer cells may be a biomarker for influenza susceptibility

Immune Cells’ Gene Expression May Predict Flu Susceptibility

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Expression of KLRD1 by natural killer cells before infection associated with influenza severity
A U.S. National Institutes of Health oversight panel will no longer review all applications for gene therapy experiments. Instead

Comments Open on End of NIH Review for Gene Therapy Studies

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NIH oversight panel no longer plans to review all applications for gene therapy experiments
A U.S. National Institutes of Health oversight panel will no longer review all applications for gene therapy experiments

NIH Panel Will No Longer Review Gene Therapy Experiments

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FDA will now assess gene therapy experiments and products as it does with other treatments, drugs
Broad-based genomic sequencing does not improve survival compared to routine genetic testing among patients with advanced non-small-cell lung cancer

Broad Genetic Testing for NSCLC May Not Improve Survival

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Compared with routine genetic testing, no improvement seen in unadjusted mortality rate
Offering cell-free DNA screening followed by invasive testing in the case of positive results does not result in a significant reduction in miscarriage among women with pregnancies at high risk of trisomy 21

cfDNA Screening First for Trisomy 21 Doesn’t Cut Miscarriage Rate

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Invasive testing if positive for trisomy 21 on cfDNA screen compared with immediate invasive testing
An ancient gene that protects elephants against cancer has been pinpointed and could lead to new ways to treat cancer in people

Ancient Gene Protects Elephants From Cancer

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The LIF6 gene destroys cells with damaged DNA
The C-509T allele in the promoter region of transforming growth factor β is associated with radiation-induced breast fibrosis risk among patients with early-stage breast cancer

TGFB1 Mutation Ups Radiation-Induced Breast Fibrosis Risk

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C-509T allele and postoperative cosmetic surgery significantly linked to breast fibrosis risk
Introduction of genomic screening into routine health care is dependent on demonstration of clinical utility

Demonstrating Clinical Use Will Speed Genomic Screening

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Field could advance more quickly if data from research participants, consumers got to clinic
Ultrarare

Molecular Autopsy May Shed Light on Sudden Death in Young

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Ultrarare, nonsynonymous variants seen in 64% of victims of sudden unexplained death in young