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Genetic testing should be made available to all patients with a history of breast cancer

Genetic Testing Recommended for All Patients With Breast Cancer

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All with personal history of breast cancer should be offered testing; updated testing recommended
In men

Endogenous Testosterone Linked to Cardiovascular Disease

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Genetically predicted endogenous testosterone may have role in thromboembolism, heart failure, MI
A gene expression signature can identify T-cell mediated rejection ahead of time in kidney transplant recipients

Blood Test Offers Early Warning for Kidney Transplant Rejection

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Monitoring for certain genes in peripheral blood samples might predict rejection before it occurs
A cell-free DNA analysis using a 73-gene panel can successfully be used to identify "Guideline-7" biomarkers in metastatic non-small cell lung cancer

Liquid Biopsy-Based Test IDs Biomarkers in Metastatic NSCLC

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Test led to increase in number of patients with identified G7 biomarker, reduction in turnaround time
Genetic variations have been identified in the ERG gene that are associated with an increased risk for acute lymphoblastic leukemia in Hispanic children

Genetic Variant Tied to Leukemia Risk in Hispanic Children

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Novel susceptibility locus identified in the ERG gene for acute lymphoblastic leukemia
The multigene expression test Oncotype DX is not cost-effective for women with breast cancer who are at low risk for recurrence

Oncotype DX Not Cost-Effective for Low-Risk Breast Cancer

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Incremental cost-effectiveness ratio varies across clinical risk groups, sensitive to patient age
The U.S. Preventive Services Task Force (USPSTF) recommends screening for women at increased risk for carrying a BRCA1/2 mutation as well as genetic counseling and testing as indicated for those screening positive. These recommendations form the basis of a draft recommendation statement published online Feb. 19 by the USPSTF.

USPSTF Says Screen Women With Higher Risk for BRCA Mutations

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Those with positive results should be provided with genetic counseling, testing if indicated
An improved type 1 diabetes (T1D) genetic risk score (GRS)

Improved Genetic Risk Score Aids Type 1 Diabetes Classification

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Revised risk score also improves newborn screening versus HLA genotyping alone
Objectively assessed physical activity is associated with a protective relationship with major depressive disorder

Objectively Assessed Exercise Protective Against Depression

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Objectively assessed, but not self-reported, physical activity protects against major depressive disorder
Among breast cancer patients

Breast Cancer Patients Do Not Overreact to Genetic Testing

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No increased cancer worry for multigene panel testing versus BRCA1/2-only test after cancer diagnosis