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Tag: Genetics

There seems to be a causal association between circulating insulin-like growth factor-1 concentrations and breast cancer

Causal Link Suggested for IGF-1 Concentrations, Breast Cancer

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In Mendelian randomization analyses, increase in genetically predicted IGF-1 linked to breast cancer
Among women with a history of gestational diabetes mellitus

Genetic Risk Linked to T2DM in Women With History of GDM

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Modest link found for genetic risk score with T2DM risk; link seems stronger for those with poorer dietary quality
In a cohort of unselected postmenopausal women with breast cancer

Genetic Mutations ID’d in Breast Cancer After Menopause

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3.55 percent of unselected postmenopausal women with breast cancer have pathogenic variants
Expansion of National Comprehensive Cancer Network hereditary cancer testing criteria to include all women diagnosed with breast cancer at ≤65 years would improve the sensitivity of detection of germline pathogenic variants

Genetic Testing Proposed for All Women ≤65 With Breast Cancer

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Expanded testing could increase detection of carriers for BRCA1/2, mutations in other predisposition genes
Receipt of molecularly matched therapy is associated with improved outcomes in patients with pancreatic cancer

Molecularly Matched Therapy Promising in Pancreatic Cancer

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Overall survival significantly longer for patients with actionable molecular alterations receiving matched tx
A proposed project to map the genes of 1 million people in New York living with or at risk for Alzheimer disease was announced Friday by Gov. Andrew Cuomo.

Alzheimer Disease Gene Mapping Project Proposed in New York State

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Governor says initiative will help researchers working to slow the progression of Alzheimer disease
Maximal resection of a contrast-enhanced tumor is associated with improved overall survival in patients with isocitrate dehydrogenase gene 1 or 2 (IDH)-wild-type and IDH-mutant subtype glioblastomas

Maximal Resection of Glioblastomas May Up Survival

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Maximal resection of contrast-enhanced tumor linked to increased overall survival across all subgroups
The genetic determinants of testosterone levels differ between the sexes

Genetic Basis for Testosterone Levels Differs According to Sex

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Genetically higher testosterone level generally benefits men, harms women in metabolic diseases
Among those who have Helicobacter pylori infection and a family history of gastric cancer in first-degree relatives

H. pylori Eradication Cuts Gastric Cancer Risk in Those With Family History

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Gastric cancer risk reduced among those with H. pylori infection plus first-degree relatives with gastric cancer
Obesity does not necessarily induce or contribute to familial psoriasis

Familial Psoriasis May Not Be Tied to Obesity

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Patients with familial psoriasis were younger, had a lower BMI at diagnosis versus nonfamilial psoriasis