Tag: Genetics

Study shows that polygenic score does not modify the 13 percent reduction in ovarian cancer risk seen with aspirin

Findings seen for major depression, bipolar disorder, schizophrenia

Increased risk for Alzheimer disease and younger age of onset seen with APOE ε3 R145C missense variation

Nonshared environmental factors explain 21 percent of the condition in twin study

Clonal hematopoiesis occurs more often in pediatric cancer survivors; is associated with exposures to alkylating agents, radiation, bleomycin

Nonmodifiable risk factors include gestational diabetes, maternal history of allergy, prenatal history of eczema

Women with germline PVs in BRCA1, BRCA2, CHEK2, and PALB2 have elevated risk for contralateral breast cancer

Implementation of precision oncology recommendations has clinical utility for patients with gastrointestinal cancers

For those with high genetic risk, hazard ratios were reduced nearly by half for favorable lifestyle versus unfavorable lifestyle

APOE ε4 carriers with favorable or average lifestyles showed slower memory decline than those with unfavorable lifestyles