Tag: Genetics
Causal Link ID’d for Plasma Caffeine Concentration With Adiposity
Higher genetically predicted plasma caffeine concentrations linked to lower risk for type 2 diabetes, with 43 percent of effect mediated by BMI
Older Women Still at Risk for Cancer With BRCA1/2 Mutations
Risk reduction surgeries before age 50 years substantially cut later cancer risk for those with genetic risk
Nine Novel Prostate Cancer Variants Identified in Men With African Ancestry
Multiancestry polygenic risk score can stratify prostate cancer risk and differentiate risk for aggressive disease
Genetic Susceptibility to Ovarian Cancer Does Not Modify Protective Effect of Aspirin
Study shows that polygenic score does not modify the 13 percent reduction in ovarian cancer risk seen with aspirin
Genetic Risk Scores Tied to Psychiatric Diagnostic Trajectories
Findings seen for major depression, bipolar disorder, schizophrenia
Certain Genetic Variant in Alzheimer Disease Linked to African Ancestry
Increased risk for Alzheimer disease and younger age of onset seen with APOE ε3 R145C missense variation
Avoidant Restrictive Food Intake Disorder Driven by Genetics
Nonshared environmental factors explain 21 percent of the condition in twin study
Study Looks at Clonal Hematopoiesis in Pediatric Cancer Survivors
Clonal hematopoiesis occurs more often in pediatric cancer survivors; is associated with exposures to alkylating agents, radiation, bleomycin
Genetic, Environmental Prenatal Risk Factors Play Role in Early Atopic Dermatitis
Nonmodifiable risk factors include gestational diabetes, maternal history of allergy, prenatal history of eczema
Risk for Contralateral Breast Cancer Higher for Certain Pathogenic Variant Carriers
Women with germline PVs in BRCA1, BRCA2, CHEK2, and PALB2 have elevated risk for contralateral breast cancer
