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Oral Semaglutide Effective for Weight Loss in Overweight or Obesity

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Estimated mean change in body weight from baseline to week 64 was −13.6 and −2.2 percent with oral semaglutide and placebo, respectively

Once-Weekly Semaglutide 7.2 mg Beats Placebo for Obesity

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Second study shows 7.2 mg semaglutide leads to greater reductions in mean body weight for those with obesity, T2D

Half Discontinue Semaglutide for Weight Loss Within One Year

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Factors tied to discontinuation included younger age, male sex, socioeconomic deprivation, higher comorbidity level

Semaglutide Not Linked to Increased Risk of Eye Disorders, Diabetic Retinopathy

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Semaglutide linked to increased risk of nonarteritic anterior ischemic optic neuropathy, but evidence remains insufficient to establish definitive conclusion

GLP-1 Receptor Agonist Use Linked to Nonarteritic Anterior Ischemic Optic Neuropathy

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Association seen in seniors with type 2 diabetes; greater associations seen for semaglutide and liraglutide

ENDO: Older Age, Female Sex Tied to Greater Muscle Loss With Semaglutide

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Higher protein intake may be protective against muscle loss, which is tied to less improvement in glucose homeostasis

Certain Factors May Predict Weight Fluctuations After GLP-1 Receptor Agonist Treatment

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Longer treatment duration, using semaglutide, higher percentage body fat, and nondiabetic status may be associated with better weight reduction

Semaglutide Offers Cardiovascular Edge Over Empagliflozin in Type 2 Diabetes

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Incidence rates of composite of death, MI, stroke were lower, but not significantly so, for patients treated with semaglutide

Semaglutide Plus Intensive Behavioral Therapy Most Beneficial for Weight Loss

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Strong outcomes seen in terms of weight loss, with lower doses of semaglutide used