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The majority of both high-risk and intermediate-risk women prefer a non-invasive cell-free prenatal DNA screening as a secondary screening test for trisomy 21

Majority of Women Prefer Non-Invasive Testing for Trisomy 21

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Yet, roughly one-third still want an invasive secondary test plus chromosomal microarray
For infants diagnosed with Down syndrome there has been a reduction in the risk of complex congenital heart defects

Decline in Complex Congenital Heart Defects in Down Syndrome

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Risk in 2010 to 2012 reduced by almost 40 percent compared with 1992 to 1994
Four methods can be used for diagnosing fetal nasal bone hypoplasia in the second trimester in order to predict Down's syndrome

Four Methods Can Diagnose Fetal Nasal Bone Hypoplasia

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Similar sensitivity for all methods for identifying fetal NB hypoplasia in second trimester
A DNA-based blood test appears to be more effective in detecting possible Down syndrome in unborn children than other screening methods

DNA-Based Blood Test More Accurate in ID of Down Sx

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But it won't eliminate need for invasive diagnostics such as amniocentesis
Exogenous progesterone seems to increase nuchal translucency

Exogenous Progesterone Increases Nuchal Translucency

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Increase also seen in women at low risk for fetal aneuploidies