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Four methods can be used for diagnosing fetal nasal bone hypoplasia in the second trimester in order to predict Down's syndrome

Four Methods Can Diagnose Fetal Nasal Bone Hypoplasia

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Similar sensitivity for all methods for identifying fetal NB hypoplasia in second trimester
A DNA-based blood test appears to be more effective in detecting possible Down syndrome in unborn children than other screening methods

DNA-Based Blood Test More Accurate in ID of Down Sx

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But it won't eliminate need for invasive diagnostics such as amniocentesis
Exogenous progesterone seems to increase nuchal translucency

Exogenous Progesterone Increases Nuchal Translucency

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Increase also seen in women at low risk for fetal aneuploidies