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Upper Airway Stimulation Effective in Teens With Down Syndrome, OSA

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73.2 percent of patients had AHI of less than 10 events/hour at 12 months; improvement also seen in quality of life

Health Supervision Discussed for Children With Down Syndrome

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Guidance provided for counseling of pregnant women with prenatal diagnosis, care of the child from infancy through adolescence

Children With Down Syndrome at Higher Risk for Leukemia

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Risk particularly high for acute myeloid leukemia before age 5 years

Gestational Age Tied to Attention-Deficit Symptoms With Down Syndrome

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Findings parallel known association in general population

Adults with Down syndrome have an increased risk for COVID-19-related death

COVID-19-Related Death Up for Adults With Down Syndrome

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Hazard ratios for COVID-19-related death, hospitalization 10.39 and 4.94 in adjusted analyses
In an evidence-based clinical guideline

Guidelines Developed for Care of Adults With Down Syndrome

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Strong recommendation advises screening for Alzheimer-type dementia starting at age 40 years
More than half of individuals with Down syndrome aged 55 years or older have dementia claims and 32.7 percent have Alzheimer disease claims

Dementia Common in Down Syndrome Patients Aged ≥55

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Dementia incidence 102 cases per 1,000 person-years for individuals aged 55 years or older
Most persons with Down syndrome maintain their personal hygiene by age 13 years and work independently by 20 years

Functional Milestones Identified for Persons With Down Syndrome

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Most maintain personal hygiene by age 13, work independently by 20; 34 percent live independently
Dementia is associated with mortality in most older adults with Down syndrome

Dementia Tied to Mortality in Older Adults With Down Syndrome

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Crude mortality rates for individuals with dementia were five times higher than for those without
Patients with Down syndrome have steeper and thinner corneas and more corneal aberrations than patients without Down syndrome

Corneal Abnormalities Seen With Down Syndrome

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More than 70 percent of patients in Down syndrome group had traits compatible with keratoconus