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Metabolic Surgery Linked to Reduced Risk for MACE After MI

Blood Biomarker May Detect Acute Heart Transplant Rejection

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Blood test measuring percent donor-derived cell-free DNA could eliminate much of the need for endomyocardial biopsy

Methylation analysis of circulating cell-free DNA sequencing can detect malignancy across stages with high specificity

Methylation Analysis of cfDNA IDs >50 Cancer Types

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Sensitivity increased with increasing stage from 39 percent in stage I to 92 percent in stage IV
Low-dose computed tomography chest examinations appear to have no biological effect on chromosomal DNA

Low-Dose Chest CT Does Not Seem to Alter Chromosomal DNA

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Increase in number of double-strand breaks, chromosomal aberrations seen with standard-dose CT
Fragmentation profiles of cell-free DNA can differentiate between patients with cancer and healthy controls

Fragmentation Profiles of Cell-Free DNA Can Detect Cancer

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Combined with mutation-based cell-free DNA analyses, 91 percent of cancer patients identified
Donor-derived cell-free DNA is a potential biomarker that can predict allograft failure after lung transplantation

Plasma Marker Predicts Allograft Failure in Lung Transplant

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Average donor-derived cell-free DNA in highest tertile linked to increased risk for allograft failure
Cell-free DNA sequencing represents an advance in genomic medicine and has associated ethical challenges

Review Addresses Cell-Free DNA Sequencing in Pregnancy

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cfDNA testing for trisomy 21, 18, 13 recommended in pregnancy; no FDA oversight for testing
About one-quarter of adults with chronic kidney disease of unknown cause or familial nephropathy or hypertension have diagnostic mutations

Diagnostic Mutations ID’d in Chronic Kidney Disease Patients

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Whole-exome sequencing identified diagnostic mutations, including PARN mutations, in two patients

Downregulation of miR-126 Augments DNA Damage Response

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Reduced miR-126 levels in lungs from mice exposed to cigarette smoke, smokers' lung epithelial cells
Capacity to repair everyday damage to cell DNA could be impaired in people who work the night shift

Shift Work May Affect the Body’s Ability to Repair DNA Damage

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Lower levels of 8-hydroxydeoxyguanosine noted in the urine of those who worked at night
The first complete genome sequence of a sample of Zika virus derived from semen has been obtained

Complete Genome Sequence of Zika Isolated From Semen

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Many answers to questions about the virus may lie in the viral genome