Tag: DNA-
Circulating Tumor DNA Can Be Detected Several Years Before Cancer Diagnosis
Same mutations detected by the multicancer early detection test at index time point could be ID'd at 8.6- to 79-fold lower mutant allele fractions
Blood-Based Screening Has Acceptable Accuracy for Colorectal Cancer Detection
In an average-risk colorectal cancer screening population, a blood-based circulating tumor DNA test is feasible
HPV Genome Sequencing Superior in Detecting Head & Neck Cancer
Whole-genome sequencing-based ctHPVDNA detection has highest sensitivity, specificity for HNSCC
Melatonin Improves DNA Damage Repair Capacity in Night Shift Workers
Melatonin intervention linked to borderline significant increase in urinary 8-OH-dG, which is indicator of oxidative DNA damage repair capacity
World Trade Center Exposure Linked to Increased DNA Methylation
WTC-exposed women more often had hypermethylated cytosine-phosphate-guanine probe sites
Low Levels of Magnesium Linked to Increased DNA Damage
Higher frequency of micronuclei, nucleoplasmic bridges seen with low magnesium, with or without high homocysteine
Early Diagnosis of High-Grade Serous Ovarian Cancer Feasible
Copy number profile abnormality values of DNA extracted from Pap samples higher from pre-HGSOC than healthy women
Concurrent RNA and DNA Sequencing Improves Variant Detection
Overall, 17.1 percent of 545 pathogenic/likely pathogenic splicing variants were dependent on RNA evidence for classification
Sample-to-Answer, Point-of-Care HPV DNA Test Feasible
Test requires six user steps and gives answer in 45 minutes
Protocol Examined for Returning Results in Genomic Research
Among participants in a biobank found to be carrying pathogenic or likely pathogenic variants, 76.3 percent unaware of these research results
