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Long-Term Gantenerumab May Slow Decline in Dominantly Inherited Alzheimer Disease

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Hazard ratio for clinical decline in Clinical Dementia Rating-Sum of Boxes was 0.53 for those treated with gantenerumab the longest

Burden of Alzheimer Disease Rose Worldwide From 1990 to 2021

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Additionally, trends show increasing cross-country inequalities, with higher burden in higher sociodemographic index regions

Increasing Sleepiness Linked to Dementia Risk in Oldest Old Women

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Individual associations with dementia also seen for sleep efficiency, wake after sleep onset, nap duration, nap frequency

Menopausal Hormone Therapy Linked to Faster Regional Tau Accumulation in Older Women

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Hormone therapy has indirect effect on cognitive decline through regional tau accumulation; no links with tau for women younger than 70 years

Music-Based Interventions May Help Short-Term Depression, Behavior With Dementia

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Review shows no evidence of long-term effects from music-based therapeutic interventions

Antidepressant Use May Speed Up Cognitive Decline in Patients With Dementia

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Associations seen for sertraline, citalopram, escitalopram, and mirtazapine

Long-Term NSAID Use Linked to Reduced Dementia Risk

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No association seen for cumulative nonsteroidal anti-inflammatory drug dose with reduced dementia risk

Decline in BMI, Waist Circumference Seen in Decade Before Dementia

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Dementia cases had lower BMI and waist circumference and faster declines; HDL levels generally higher predementia

Variability in Total Cholesterol, LDL Cholesterol Linked to Dementia

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Higher variability also linked to cognitive impairment with no dementia and with faster decline in global cognition, episodic memory

Intensive BP Control Linked to Long-Term Cognitive Benefits

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Rates of both MCI and composite of MCI or probable dementia lower with intensive treatment in extended follow-up study