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FDA Approves Nucala for Chronic Obstructive Pulmonary Disease

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Approval is for adult patients with COPD with eosinophilic inflammation

Persistent, New Mucus Plugs Associated With Faster Decline in FEV1 in COPD

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The steepest decrease in FEV1 seen for those with persistently positive mucus plugs who resume smoking

Mepolizumab Yields Lower Rate of Moderate/Severe Exacerbations in COPD

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Time to first moderate or severe exacerbation longer with mepolizumab in patients with COPD, history of exacerbations, eosinophil count ≥300 cells/µL

Women Have Higher Risk for COPD Than Men, Regardless of Smoking History

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Female gender linked to increased chronic obstructive pulmonary disease risk in those with and without a history of smoking

Higher Stress Tied to Worse Respiratory Outcomes With COPD

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Platelet activation, oxidative stress may be pathways impacted by increased perceived stress, authors say

Adverse Outcomes Increased With Long-Term Inhaled Corticosteroids in COPD

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Significantly greater composite adverse outcome rates seen for long- versus short-term inhaled corticosteroid use for prevalent, inception cohorts

COPD Tied to Increased Risk for Death in Patients With Arthritis

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Findings seen for both all-cause and cardiovascular disease mortality

Certain Glucose-Lowering Meds Associated With Lower Risk for COPD Exacerbations

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Lower risk for COPD exacerbations seen with SGLT-2 inhibitors and GLP-1 receptor agonists, but not with DPP-4 inhibitors

Injurious Falls Common in Last Years of Life With COPD

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Odds for use of fall risk-increasing drugs higher in those with falls versus without

Beginning to Smoke Before Age 15 Increases Risk for COPD

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Findings independent of cigarette pack years, current smoking status, secondhand smoke exposure