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The American Society of Hematology has developed new guidelines for the treatment of venous thromboembolism; the clinical practice guidelines were recently published in Blood Advances.

ASH Develops Practice Guidelines for Venous Thromboembolism

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Clinical practice guidelines presented for diagnosis, treatment, pediatric and pregnancy-linked VTE
Among patients with cancer starting chemotherapy who are at intermediate-to-high risk

Apixaban Prevents VTE in Cancer Patients Initiating Chemotherapy

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Major bleeding occurred in more apixaban-treated than control patients
Rivaroxaban can prevent venous thromboembolism in cancer patients at increased risk

ASH: Rivaroxaban Prevents Blood Clots in At-Risk Cancer Patients

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Risk for patients in rivaroxaban group reduced during the on-treatment period
Among older patients with polycythemia vera

Recommended Therapies for Polycythemia Vera Underused

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Phlebotomy and hydroxyurea tied to improved survival, lower risk for thrombosis in older patients
The use of a clinical decision support system in the emergency department can improve outpatient management for patients with acute pulmonary embolism

Clinical Decision Support System Ups Outpatient PE Management

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Home discharge rate increased at intervention sites; no increase in return visits, adverse outcomes
A patient-centered education bundle intervention can reduce nonadministration of venous thromboembolism prophylaxis

Patient Education Ups VTE Prophylaxis in Hospital Setting

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Targeted patient-centered intervention reduces nonadministration of pharmacologic prophylaxis
A diagnostic strategy based on pretest clinical probability assessment

Diagnostic Strategy Can Rule Out PE in Pregnant Women

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Strategy includes clinical probability assessment, D-dimer, lower-limb compression ultrasound, CTPA
Among patients undergoing total knee arthroplasty

Aspirin, Anticoagulants Similarly Prevent VTE After TKA

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In patients having total knee arthroplasty, aspirin non-inferior for venous thromboembolism, death
The risk of recurrence after incident venous thromboembolism is high

Risk of Venous Thromboembolism Recurrence High

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At 6 months, rates for provoked, unprovoked, cancer-related VTE are 6.8, 6.92, 9.06 per 100 person-years
Rivaroxaban does not lower risk of symptomatic venous thromboembolism and related death in medical patients after hospital discharge

No Clear Benefit for Rivaroxaban After Hospital Discharge

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Incidence of major bleeding low with rivaroxaban, but clot risk not lower