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Testing of the Eli Lilly antibody drug for hospitalized COVID-19 patients has been halted because the treatment does not help them recover from their infection.

Trial of Antibody Drug for COVID-19 Stopped for Lack of Effectiveness

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Eli Lilly says government is continuing a separate study testing the antibody drug in mild to moderately ill patients
Drugmakers AstraZeneca and Johnson & Johnson are ready to resume paused COVID-19 vaccine trials after health scares

AstraZeneca, J&J Resume U.S. COVID-19 Vaccine Trials

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U.S. Food and Drug Administration authorized the restart after reviewing all safety data
The first company to start a phase 3 trial of a COVID-19 vaccine reached its target of enrolling 30

U.S. COVID-19 Vaccine Trial Enrolls 30,000

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Moderna says it is on track to apply for FDA approval to market the vaccine in early December
Long-term survival analysis shows that patients with earlier initiation of sodium phenylbutyrate-taurursodiol treatment for amyotrophic lateral sclerosis have longer median overall survival

Investigational Drug May Prolong Survival in Patients With ALS

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Median survival 6.5 months longer with initiation of PB-TURSO treatment compared with placebo
British scientists are infecting healthy volunteers with COVID-19

Scientists to Infect Volunteers With COVID-19 in Challenge Trial

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Challenge trials have long history, going back to development of smallpox vaccine in 1796
Upadacitinib is superior to abatacept for patients with rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs

Upadacitinib Tops Abatacept for RA Refractory to DMARDs

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Superior for mean change in composite DAS28-CRP values and remission, but more adverse events seen
Manualized psychotherapy interventions combined with pharmacotherapy seem beneficial for bipolar disorder

Pharmacotherapy, Psychotherapy Combo Best for Bipolar Disorder

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Manualized treatments linked to significantly reduced recurrence rates versus control treatments
Ertugliflozin is noninferior to placebo with respect to major adverse cardiovascular events among patients with type 2 diabetes and atherosclerotic cardiovascular disease

Ertugliflozin Noninferior for CV Outcomes in T2DM With ASCVD

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Ertugliflozin is noninferior to placebo for the primary end point of major adverse cardiovascular events
A study to assess whether certain approved or experimental drugs are effective against COVID-19 and warrant testing in large clinical trials has been launched by the U.S. National Institutes of Health (NIH).

NIH Launches Trial of Antibody Drugs Against COVID-19

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The phase 2 trial will assess effectiveness of monoclonal antibodies in conjunction with remdesivir
Enrollment in a study testing an experimental antibody therapy against COVID-19 has been paused by independent monitors.

COVID-19 Antibody Treatment Study Paused

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ACTIV-3 study, testing use of an antibody therapy with remdesivir, paused 'out of an abundance of caution'