Tag: Clinical Trials
CHEST: Nerandomilast Slows Decline in FVC in Idiopathic Pulmonary Fibrosis
No significant difference seen in composite end point of acute exacerbation, hospitalization for respiratory cause, or death
Cannabis Extract VER-01 Safe, Effective for Chronic Low Back Pain
Recent study met primary end point of reduction of numeric rating scale pain intensity in double-blind 12-week treatment phase
Oral Semaglutide Effective for Weight Loss in Overweight or Obesity
Estimated mean change in body weight from baseline to week 64 was −13.6 and −2.2 percent with oral semaglutide and placebo, respectively
Women Still Underrepresented in Cardiovascular Trials
Lowest representation seen for studies on arrhythmia, coronary heart disease, acute coronary syndrome, and heart failure
Peer Review, Editorial Process Yield Improvements in RCT Abstracts
59 percent of abstracts improved, with the conclusion the most frequently modified domain
Many Ineligible for Clinical Trial Could Benefit From Teclistamab for Multiple Myeloma
89 percent of 509 patients would have been ineligible for MajesTEC-1 trial; estimated median PFS was 5.8 months
Approved-Label Populations for New Drugs Broader Than Trial Populations
Inconsistency seen most often in terms of patient fitness, with variance in almost all approved indications
Shorter-Form Messaging May Be Preferable for Trial Recruitment
Enrollment in DANFLU-2 trial was significantly more likely for those receiving single-page letter versus two-page letters
NIH Research Cuts Leave Cancer Patient Facing Hard Choice
Semaglutide May Reduce Craving in Alcohol Use Disorder
Phase 2 trial shows significant reduction in drinks per drinking day and weekly alcohol craving
