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Tag: Cancer: Prostate

The larger a man

Tall, Obese Men at Higher Risk of Aggressive Prostate Cancer

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Study found taller, heavier males were more likely to develop prostate cancer, die from it
For patients newly diagnosed with prostate cancer who attend a multidisciplinary clinic

Decisional Regret Doesn’t Differ by Treatment in Prostate Cancer

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Only African-American race was associated with greater regret across time
Germline deleterious mutations are enriched among men with prostate cancer and at least one additional primary cancer

Germline Mutations Up in Men With Prostate CA, One Other CA

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However, most of these men do not meet current clinical criteria for germline testing
Dutasteride for the treatment of benign prostatic hyperplasia may induce imbalance in metabolic function

Dutasteride Associated With Metabolic Safety Concerns

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Use of medication in BPH linked to higher hemoglobin A1c and LDL cholesterol levels
Novel biomarkers have been identified that may have utility for predicting prostate cancer in non-African-American men

Novel Biomarkers Identified for Prostate Cancer in Non-Blacks

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PCA3 and T2ERG add utility for predicting prostate cancer when combined with PCPT risk calculator
In men with advanced prostate cancer

ASCO: Abiraterone Extends Survival in Metastatic Prostate CA

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Side effects noted with use of abiraterone similar to those already found in patients taking the drug
Diagnosis of subsequent metastases is associated with substantially increased costs and medical resource use among patients initially diagnosed with localized prostate cancer

Substantial Increase in Costs With Metastases in Prostate CA

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Costs peak during month of metastases diagnosis, reaching $13,291
Testing for combined urinary PCA3 and TMPRSS2:ERG RNA can improve detection of prostate cancer

Combined Urine Test for T2:ERG, PCA3 Ups Prostate CA Detection

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Combined urinary testing can avoid unnecessary prostate biopsy, while preserving high sensitivity
Distinct clinical outcomes are seen for luminal- and basal-like prostate cancers

Distinct Outcomes for Luminal-, Basal-Like Prostate Cancers

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Luminal B prostate cancers exhibited poorest clinical prognosis in univariate, multivariate analyses
Black men appear to have a higher incidence of preclinical prostate cancer and a higher risk of metastatic progression than the general population

Black Men Have Higher Rate of Preclinical Prostate Cancer

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Also increased risk of progression to metastatic disease compared with the general population