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Tag: Cancer: Lung

Existing tobacco control efforts will continue to reduce lung cancer mortality through 2065

Models Project 79 Percent Drop in Lung CA Mortality by 2065

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Annual number of deaths expected to continue to decrease despite growth, aging of U.S. population
The use of angiotensin-converting enzyme inhibitors is associated with an increased risk for lung cancer compared with angiotensin receptor blockers

Angiotensin-Converting Enzyme Inhibitors May Up Lung CA Risk

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Higher risk seen with ACEIs versus angiotensin receptor blockers; risk linked to duration of use
Durvalumab results in significantly longer overall survival than placebo among patients with stage III

Durvalumab Extends Survival in Stage III Non-Small Cell Lung CA

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Both overall and progression-free survival longer with durvalumab than with placebo
Thermal ablation is a safe

Thermal Ablation Acceptable for Early Lung Cancer

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Regarding overall survival, thermal ablation non-inferior to radiation for primary treatment
Integration of plasma next-generation sequencing into the routine management of metastatic non-small cell lung cancer results in an increase in the detection of therapeutically targetable mutations

Plasma-Based Genotyping Aids Targeted Tx of Metastatic NSCLC

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Most patients who received targeted therapy based on plasma result achieved clinical response
Among patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer who have not previously received an ALK inhibitor

In NSCLC, Longer Survival With Brigatinib Than Crizotinib

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Longer progression-free survival in those with ALK-positive dz who did not previously take ALK inhibitor
An integrated plasma proteomics classifier

Integrated Classifier Identifies Benign Lung Nodules

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Classifier integrates relative abundance of two plasma proteins with clinical risk prediction model
The quality of shared decision-making about the initiation of lung cancer screening is poor

Poor Shared Decision-Making for Lung Cancer Screening

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Physicians universally recommended screening, with almost no discussion of harms
Broad-based genomic sequencing does not improve survival compared to routine genetic testing among patients with advanced non-small-cell lung cancer

Broad Genetic Testing for NSCLC May Not Improve Survival

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Compared with routine genetic testing, no improvement seen in unadjusted mortality rate
Biomarker-based risk profiling has the potential to improve lung cancer risk assessment

Biomarker Panel May Improve Lung Cancer Risk Assessment

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Risk score based on panel of four circulating protein biomarkers