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Tag: Cancer: Colon

Adding surveillance to fecal immunochemical test screening reduces colorectal cancer mortality and increases colonoscopy demand

Adding Surveillance to FIT Screening Cuts CRC Mortality

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But addition of surveillance is not cost-effective based on Dutch incremental cost-effectiveness ratio
Administration of histamine-producing gut microbes to histidine decarboxylase-deficient mice reduces inflammation and tumor formation

Histamine May Play Role in Colorectal Tumorigenesis

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Histamine-producing probiotic reduces inflammation, suppresses colon tumors in mice
Monthly feedback significantly improves colonoscopy quality measures

Monthly Feedback Linked to Improved Colonoscopy Quality

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But no improvement observed with quarterly feedback
Programmed death-ligand 1 is primarily expressed in metastatic colorectal cancer lesions

PD-L1 Mainly Expressed in Metastatic CRC Lesions

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Overall, 81.8 percent of metastatic CRCs and 40.9 percent of primary lesions had PD-L1 expression
There is strong evidence that physical activity and a healthy diet reduce the risk of colorectal cancer

Strong Evidence for Healthy Lifestyle Reducing CRC Risk

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Consuming whole grains, foods with dietary fiber, dairy products reduces risk of colorectal cancer
Mailed outreach invitations offering a fecal immunochemical test (FIT) or colonoscopy increase the proportion of participants completing colorectal cancer screening

Mailed Invitations Increase CRC Screening Completion

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And providing specific reminders to general practitioners improves participation in FIT screening
Gut microbes may promote cytotoxic T-cell infiltration in tumors

CRC Tumor Cells Exposed to Gut Bacteria Express Chemokines

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Antibiotic treatment of orthotopic tumor-bearing mice reduced chemokine expression levels
Screening with flexible sigmoidoscopy reduces all-cause mortality

Flexible Sigmoidoscopy Screening Reduces Mortality

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Reduction in all-cause mortality at 11 to 12 years using data from individual NORCCAP study cohorts
Colorectal cancer mortality rates have decreased since 1970 in black adults (aged 20 to 54 years)

Colorectal Cancer Mortality Rates Down in Blacks, Up in Whites

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Among adults aged 20 to 54 years, increase in CRC mortality only seen in whites aged 30 to 54 years

Centralized Mailings Can Improve CRC Screening Adherence

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Participants randomized to receive mailings had 31 percent more adjusted covered time over five years