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Tag: Cancer: Colon

Higher HER3 expression is associated with improved survival with the addition of panitumumab treatment for patients with RAS wild-type advanced colorectal cancer

HER3 Linked to Improved Survival With Panitumumab

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Addition of panitumumab to irinotecan tied to improved survival in RAS wt advanced colorectal CA
For patients undergoing left colon and rectal cancer resections

Oral Antibiotics Cut Risk of SSI in Colorectal CA Resection

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Adding antibiotics to mechanical bowel preparation linked to reduced rate of surgical site infection
Adding surveillance to fecal immunochemical test screening reduces colorectal cancer mortality and increases colonoscopy demand

Adding Surveillance to FIT Screening Cuts CRC Mortality

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But addition of surveillance is not cost-effective based on Dutch incremental cost-effectiveness ratio
Administration of histamine-producing gut microbes to histidine decarboxylase-deficient mice reduces inflammation and tumor formation

Histamine May Play Role in Colorectal Tumorigenesis

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Histamine-producing probiotic reduces inflammation, suppresses colon tumors in mice
Monthly feedback significantly improves colonoscopy quality measures

Monthly Feedback Linked to Improved Colonoscopy Quality

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But no improvement observed with quarterly feedback
Programmed death-ligand 1 is primarily expressed in metastatic colorectal cancer lesions

PD-L1 Mainly Expressed in Metastatic CRC Lesions

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Overall, 81.8 percent of metastatic CRCs and 40.9 percent of primary lesions had PD-L1 expression
There is strong evidence that physical activity and a healthy diet reduce the risk of colorectal cancer

Strong Evidence for Healthy Lifestyle Reducing CRC Risk

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Consuming whole grains, foods with dietary fiber, dairy products reduces risk of colorectal cancer
Mailed outreach invitations offering a fecal immunochemical test (FIT) or colonoscopy increase the proportion of participants completing colorectal cancer screening

Mailed Invitations Increase CRC Screening Completion

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And providing specific reminders to general practitioners improves participation in FIT screening
Gut microbes may promote cytotoxic T-cell infiltration in tumors

CRC Tumor Cells Exposed to Gut Bacteria Express Chemokines

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Antibiotic treatment of orthotopic tumor-bearing mice reduced chemokine expression levels
Screening with flexible sigmoidoscopy reduces all-cause mortality

Flexible Sigmoidoscopy Screening Reduces Mortality

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Reduction in all-cause mortality at 11 to 12 years using data from individual NORCCAP study cohorts