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Tag: Cancer: Breast

PARP inhibitors demonstrate activity in triple-negative breast cancer tumors without BRCA1/2 mutations

PARP Inhibitors Promising Beyond BRCA1/2 Altered Tumors

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Talazoparib caused regression in 5 patient-derived xenografts, 4 without germline BRCA1/2 mutations
The combination of elastography and color Doppler ultrasonography with B-mode US in women with dense breasts can increase the positive predictive value of screening and reduce the number of false-positives

Elastography and Color Doppler Improve Breast Ultrasound

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Together, the technologies increase predictive value of screening while decreasing unnecessary biopsies
Automated breast ultrasonography may not be of added value to yearly full-field digital mammography and dynamic contrast agent-enhanced magnetic resonance imaging surveillance of carriers of the BRCA mutation

Multimodal Surveillance Regimen May Not Benefit BRCA Carriers

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Biannual automated breast ultrasound may not add value to annual mammography, MR imaging
The 70-gene signature assay affects treatment decisions among physicians treating patients identified as being at intermediate risk with the 21-gene assay

70-Gene Signature Impacts Treatment Decisions in Breast CA

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70-GS linked to change in treatment decisions for intermediate-risk patients based on 21-gene assay
Swedish massage therapy is associated with clinically significant relief from cancer-related fatigue in breast cancer survivors

Swedish Massage May Reduce Cancer-Related Fatigue

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For breast cancer survivors, larger drop in fatigue scores with Swedish massage than light touch
Cryotherapy may be useful for preventing symptoms of chemotherapy-induced peripheral neuropathy

Cryotherapy May Prevent Chemo-Induced Neuropathy

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Breast cancer patients on paclitaxel had lower incidence of peripheral neuropathy with cryotherapy
A machine learning model can predict the risk of upgrade of high-risk breast lesions to cancer

Machine Learning Model Predicts Risk of Upgrade to Breast CA

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Model can predict risk of upgrade of high-risk breast lesions to cancer using traditional, text features
From 2009 to 2014 there was an increase in the population rate of breast reconstruction for mastectomy

Increase in Rate of Breast Reconstruction for Mastectomy

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From 2009 to 2014, increases for all age groups, especially for women aged 65 years and older
For patients at high risk for breast cancer

Provider Advice Impacts Breast Cancer Prevention Decisions

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Worry, trust also affect choice on whether to use selective estrogen receptor modulators
Overall breast cancer incidence rates increased among specific racial/ethnic groups from 2005 to 2014

Overall Breast Cancer Incidence Up for Some in 2005-2014

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Incidence up for Asian/Pacific Islanders, non-Hispanic blacks, Hispanics, not non-Hispanic whites