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Concentrations of cerebrospinal fluid β42-amyloid 42 derived from new immunoassays may show improved agreement with visual flutemetamol F18-labeled positron emission tomography assessment

Benefits for New Immunoassays for Measuring Aβ42 in CSF

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May show improved correlation with mass spectrometry reference measurement procedure
For patients with chronic valvular heart disease

Brain Measures Tied to Atrial Pressure in Valvular Heart Dz

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Linear link between white matter hyperintensity volume, RA pressure in chronic valvular heart disease
Systemic inflammation in midlife is associated with future neurodegeneration and cognitive aging

Midlife Systemic Inflammation Tied to Late-Life Brain Volume

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Smaller hippocampal, Alzheimer's signature region volumes seen 24 years after inflammation noted
Black men have increased prevalence and frequency of multiple intracranial atherosclerotic plaques

Race a Factor in Intracranial Atherosclerotic Disease

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Prevalence and frequency of multiple plaques were higher for black men
Hypothermia treatment initiated at six to 24 hours after birth for newborns with hypoxic-ischemic encephalopathy may reduce death or disability

Hypothermia May Help Newborns With Encephalopathy

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Appears to reduce death, disability in infants with encephalopathy, but effectiveness uncertain

September 2017 Briefing – Neurology

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Here are what the editors at HealthDay consider to be the most important developments in Neurology for September 2017. This roundup includes the latest...
For patients with progressive multifocal leukoencephalopathy

Caution for PLEX in Progressive Multifocal Leukoencephalopathy

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Plasma exchange not linked to PML immune reconstitution inflammatory syndrome latency
Patients with severe neurotoxicity after infusion of CD19-targeted chimeric antigen receptor-modified T cells have evidence of endothelial activation

Neurotoxicity Characterized After Infusion of CD19 CAR-T Cells

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Patients with severe neurotoxicity have endothelial activation, increased BBB permeability
Early results suggest that stem cell gene therapy is a safe and effective treatment for boys with early-stage cerebral adrenoleukodystrophy

Stem Cell Gene Therapy Safe for Adrenoleukodystrophy

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No treatment-related deaths, graft-versus-host-disease reported in interim analysis
For clinically healthy older adults

Subjective Cognitive Decline Linked to Global Tau Burden

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Greater SCD tied to increasing entorhinal cortical tau burden, Aβ burden in clinically healthy elderly