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New antibiotic therapy

New Antibiotic Tx Beneficial After Acute Lung Function Decline in CF

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Findings among children with cystic fibrosis treated either inpatient, outpatient
Children with tympanostomy tube placement exposed to quinolone ear drops may have an increased risk of perforations requiring tympanoplasty

Quinolone Ear Drops Increase Perforation Risk With Ear Tubes

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Risk of perforation may be further exaggerated by ear drops with quinolone plus corticosteroids
Despite widespread use

Antibiotics Ineffective for Mildly Infected Eczema in Children

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Rapid resolution seen in response to topical steroid and emollient treatment
For children with community-acquired pneumonia

Nonclinical Factors Drive Antibiotic Choice in Pediatric CAP

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Age, previous antibiotic receipt, private insurance up odds of macrolide versus amoxicillin receipt
Implementation of the American Academy of Pediatrics guidelines of watchful waiting for acute otitis media is cost-effective

Watchful Waiting Cost-Effective for Pediatric Acute Otitis Media

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For every 1,000 patients with AOM, WW would result in 205 fewer antibiotic prescriptions used
Oral ciprofloxacin is effective for the treatment of human plague

Oral Ciprofloxacin Effective for Treatment of Human Plague

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Successful treatment in 5 cases of culture-confirmed human plague, including 1 case of pneumonic plague
For patients with metastatic renal cell carcinoma receiving immune checkpoint inhibitors

ASCO: Antibiotics May Have Negative Impact in Renal Cancer

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Progression-free survival down with antibiotic use for patients receiving immune checkpoint inhibitors
Doctors are more likely to prescribe antibiotics if they think patients expect the medications

Doctors Often Write Rx for Antibiotics If Patients Expect It

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Findings held true even if doctor did not suspect bacterial infection
Avoiding surgery and treating appendicitis with antibiotics alone may be a safe approach for many children

Antibiotics Could Be Alternative to Surgery for Appendicitis

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Findings from review of uncomplicated appendicitis cases
Concomitant use of valproic acid and meropenem is associated with a decrease in valproic acid plasma levels

Valproic Acid Plasma Levels Down With Concomitant Meropenem

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Concomitant use of meropenem linked to decrease in VPA plasma level, regardless of MEPM dose