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Very young children with urinary tract infections who receive parenteral antibiotics before emergency department discharge do not have lower rates of revisits leading to admission than children receiving oral antibiotics

Pediatric Revisits, Admissions for UTI Similar With Oral or IV Meds

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Findings support ED discharge with oral antibiotics for children with urinary tract infection
Changing from intravenous to oral antibiotic treatment is non-inferior to continued intravenous antibiotic treatment among patients with endocarditis on the left side of the heart

Partial Oral Abx Non-Inferior in Endocarditis on Left Side of Heart

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Changing to oral antibiotics was non-inferior to continued intravenous antibiotic treatment
Emergency department visits for antibiotic adverse drug events (ADEs) in children account for 46.2 percent of emergency department visits for ADEs resulting from systemic medication

Many ED Visits for Antibiotic Adverse Drug Events in Children

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Antibiotic ADEs among children account for 46.2 percent of ED visits for ADEs tied to systemic meds
In pretreatment isolates of Mycobacterium tuberculosis

MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse

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Higher MIC in pretreatment M. tuberculosis isolates linked to relapse risk
The U.S. Food and Drug Administration is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin

FDA Warns Against Long-Term Azithromycin Use for Some

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Warning for blood cancer patients who have undergone donor stem cell transplant
Individuals with bicuspid aortic valve and mitral valve prolapse have a higher risk of developing infective endocarditis than the general population

Infective Endocarditis More Common with Valve Issues

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Antibiotic prophylaxis should be reconsidered with bicuspid aortic valve, mitral valve prolapse
There are significant variations in practice patterns and resource utilization in patients treated by teaching staff for acute exacerbations of chronic obstructive pulmonary disease

Variations in Practice Patterns Seen in Patients Treated for COPD

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Differences in use of steroids, antibiotics noted between teaching and non-teaching hospital staff
There is considerable variability in the proportion of visits at which antibiotics are prescribed among traditional medical and retail clinic settings

Inappropriate Prescribing of Abx High in Urgent Care Centers

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Patterns of antibiotic prescribing vary substantially by care setting
The U.S. Food and Drug Administration has strengthened current warnings in the prescribing information about fluoroquinolone antibiotics causing significant decreases in blood glucose as well as mental health side effects.

FDA Requires Safety Label Changes for Fluoroquinolones

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Changes will describe hypoglycemic coma and clarify and identify mental health side effects
Between 1999 and 2012

Resistant A. Baumannii Rose in Children From 1999 to 2012

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Increase seen carbapenem- and cephalosporin-resistant strains, with peak in 2008