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Tag: Alzheimer’s

Most cerebrovascular risk factors are associated with an increased risk for subsequent diagnosis of Parkinson disease

Cerebrovascular Risk Factors May Up Risk for Parkinson Disease

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Most cerebrovascular risk factors linked to higher risk for subsequent diagnosis of Parkinson disease
Plasma β-amyloid (Aβ)42/Aβ40 corresponds with amyloid positron emission tomography status

Plasma Assay Promising for Diagnosis of Early Alzheimer Disease

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Aβ42/Aβ40, age, and APOE ε4 status combination corresponds with amyloid PET with AUC of 0.94
A staging system of β-amyloid accumulation may be useful for monitoring patients throughout the course of Alzheimer disease

Novel PET Staging System May Help Monitor Alzheimer Disease

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Positron emission tomography used to track stages of β-amyloid accumulation in vivo
Greater physical activity and lower vascular risk are associated with slower β-amyloid-related cognitive decline in clinically normal older adults

Physical Activity Linked to Slower Aβ-Related Cognitive Decline

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Exercise, lower vascular risk independently attenuate negative link for Aβ burden, cognitive decline
A first-degree family history of dementia is associated with memory deficits decades before the typical onset of Alzheimer disease

Family History of Dementia Tied to Early Memory Deficits

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Reduced paired-associates learning performance observed long before typical onset of Alzheimer disease
Exposure to anticholinergic drugs is associated with an increased dementia risk

Exposure to Anticholinergics May Increase Dementia Risk

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Risk up for exposure to anticholinergics including antidepressants, antiparkinson drugs, antipsychotics
For patients with mild-to-moderate Alzheimer disease

Nilvadipine Increases Cerebral Blood Flow in the Hippocampus

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CBF did not significantly change in posterior cingulate cortex, other regions of interest in Alzheimer disease
An entorhinal cortex-based virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk for developing dementia

Virtual Reality IDs Navigation Issues in Early Alzheimer Disease

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Classification accuracy superior to cognitive tests considered highly sensitive to early disease
Low-density lipoprotein cholesterol is associated with the probability of developing early-onset Alzheimer disease

Higher LDL-C Levels Linked to Early-Onset Alzheimer Disease

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Cases with EOAD have higher levels of LDL-C, greater frequency of rare genetic coding variants of APOB
Community-dwelling patients with Alzheimer disease experience a lower risk for fractures

Thiazide Use May Lower Fracture Risk in Patients With Alzheimer Disease

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Longer thiazide use tied to decreased risk for low-energy fractures, hip fractures in Alzheimer disease