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Review: No Blood Pressure Lowering Effect for Vitamin D

No reductions in systolic, diastolic BP in trial-level analysis, individual patient data analysis

TUESDAY, March 17, 2015 (HealthDay News) — Vitamin D supplementation is not associated with a reduction in blood pressure, according to a systematic review and meta-analysis published online March 16 in JAMA Internal Medicine.

Louise A. Beveridge, M.B., Ch.B., from the University of Dundee in the United Kingdom, and colleagues conducted a systematic review to examine whether supplementation with vitamin D or vitamin D analogues reduced blood pressure. Data were included from 46 trials with 4,541 participants in a trial-level meta-analysis. Individual patient data were included for 3,092 participants in 27 trials.

The researchers found that vitamin D supplementation had no effect on systolic blood pressure (effect size, 0.0 mm Hg; P = 0.97) or diastolic blood pressure (effect size, −0.1 mm Hg; P = 0.84) at the trial level. Similar results were seen on analysis of individual patient data (systolic blood pressure: effect size, −0.5; P = 0.27; diastolic blood pressure: effect size, 0.2; P = 0.38). No baseline factor was found to predict a better response to therapy in subgroup analysis.

“Vitamin D supplementation is ineffective as an agent for lowering blood pressure and thus should not be used as an antihypertensive agent,” the authors write.

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