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A timed in vitro prion protein conversion protocol is sensitive for detecting elk chronic wasting disease in brain tissues

New Assay May Help Improve Detection of Prion Diseases

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Assay as sensitive for elk chronic wasting disease as two bioassay models, more sensitive than rapid test
For most patients with chronic pancreatitis

Optimized Tx Linked to Lasting Pain Relief in Chronic Pancreatitis

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Significant pain relief achieved in 84.7 percent of patients at one-year follow-up; most with medical tx
For children with atopic dermatitis

Clinical Scores Correlate Well in Pediatric Atopic Dermatitis

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Clinical scores for sleep loss, pruritus correlate well with each other and with disease severity, QoL
For older adults

Low Fruit, Vegetable Intake Linked to Hip Fracture Risk

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Daily intake of one or less servings of fruit and vegetables linked to increased risk in older adults
Implementation of a computerized multidisciplinary order set in the electronic health record improves the quality of physician pharmacologic prescribing for patients hospitalized for chronic obstructive pulmonary disorder exacerbations

Computerized Order Set Aids Prescribing in COPD Exacerbations

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Increase in percentage of patients receiving all recommended pharmacologic therapies
The implementation of a multicomponent electronic clinical decision support tool reduces computed tomography use for pediatric patients with possible appendicitis

Clinical Decision Support Tool Cuts CT Use for Appendicitis

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Multicomponent electronic clinical decision tool reduces CT use in children with possible appendicitis
The offspring of women using ondansetron early in pregnancy for nausea and vomiting of pregnancy or hyperemesis gravidarum may be at risk for cardiac abnormalities

Review: Low Risk of Birth Defects With Ondansetron Exposure

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Ondansetron-exposed neonates may have small increase in incidence of cardiac abnormalities
Blockade of histamine 1 and 4 receptors in peanut challenge can combine to prevent development of intestinal allergic responses

Histamine Receptor Blockade Stops Peanut-Induced Response

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Histamine 1 and 4 receptors involved in intestinal allergic responses in mouse model of peanut allergy
For older adults starting antimuscarinic treatment for overactive bladder

Potentially Inappropriate Meds Use Common With OAB Tx

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For older adults initiating antimuscarinic medication for overactive bladder, PIM is prevalent
Use of the word "breakthrough" in the U.S. Food and Drug Administration's expedited approval process could mislead doctors about the new drugs' actual benefits

Doctors Can Be Misled About FDA ‘Breakthrough’ Drug Designation

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Many believe meds supported by stronger evidence than the law requires to achieve designation