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Cytokines and chemokines produced by pancreatic islets in response to inflammatory and metabolic stress include interferon gamma-induced protein 10

Islet-Released Mediators Impact Transplant Outcome

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IP10 is among highest-released, with high levels linked to poor islet transplant outcomes
For patients with acute diverticulitis

Acute Diverticulitis Recurrence More Likely With Barium Enema

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Patients who undergo barium enema are more likely to present with higher Hinchey grade at recurrence
Mailed outreach invitations offering a fecal immunochemical test (FIT) or colonoscopy increase the proportion of participants completing colorectal cancer screening

Mailed Invitations Increase CRC Screening Completion

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And providing specific reminders to general practitioners improves participation in FIT screening
Injection of inactivated modified vaccinia virus Ankara into tumors is effective and generates antitumor immunity

Inactivated Vaccinia Virus Shows Promise Against Advanced Cancer

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Combined with immune checkpoint blockade therapy, iMVA generates synergistic antitumor effects
Outcomes of treatment with third-generation CAR T-cell therapy in CD19-positive B-cell malignancy are associated with patients' immune status

Immune Status Tied to Outcomes in Third-Gen CAR T-Cell Therapy

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In leukemia/lymphoma, after treatment CD19-targeting chimeric antigen receptor T-cell therapy
Asking patients to stop smoking before undergoing cosmetic surgery can promote long-term smoking cessation

Pre-Cosmetic Sx Advice May Aid Long-Term Smoking Cessation

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More than 40 percent of 42 daily smokers were no longer smoking cigarettes at long-term follow-up
For adolescent men who have sex with men participating in a 48-week HIV pre-exposure prophylaxis intervention

PrEP Adherence Decreases Over Time in Adolescent MSM

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Findings in diverse sample of adolescent men who have sex with men who are at risk for HIV
Re-analysis of evidence suggests that screening does reduce prostate cancer mortality

Re-Analysis Shows Screening Reduces Prostate CA Mortality

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In re-analysis, screening conferred 7 to 9 percent reduction in risk in ERSPC and PLCO trials
Appropriate use criteria have been developed for valvular heart disease imaging tests

New Appropriate Use Criteria Issued for Valvular Heart Disease

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Report gives rating of multiple imaging modalities in real-world clinical scenarios to guide physicians
The U.S. Preventive Services Task Force recommends screening 3- to 5-year-old children for amblyopia

USPSTF Recommends Amblyopia Screening for 3- to 5-Year-Olds

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Inadequate evidence is available to assess benefits and harms of screening in those younger than 3