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Among patients with moderately severe Parkinson disease

SAE Rate Higher With Nilotinib Versus Placebo in Parkinson Disease

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Exploratory biomarkers altered in response to nilotinib, including drop in hyperphosphorylated tau
Regional anesthesia may aid pain management if used soon after traumatic injury of the extremities

Early Regional Anesthesia Effective for Extremity Injury Pain

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When given soon after traumatic injury, regional anesthesia is valuable pain management intervention
Emergency department patients presenting with deliberate self-harm or suicidal ideation are at substantially increased risk for suicide in the year following discharge

Suicide 30 to 50 Times Higher After ED Visit for Self-Harm, Suicidal Ideation

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Findings seen among patients presenting with self-harm and suicidal ideation in California
For acutely ill adults

Hospital-Level Home Acute Care Can Cut Costs, Health Care Use

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Less frequent readmission seen within 30 days with hospital-level care at home for acutely ill
Nearly one in 10 patients admitted to a hospital with no symptoms of diarrhea may be a carrier of Clostridioides difficile

One in 10 Hospital Patients May Carry C. Diff at Admission

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Asymptomatic carriers of C. difficile at significant risk for progression to symptomatic infection
Black-white patterns in subtype-specific breast cancer incidence rates differ for men and women

Black Men Have Higher Breast Cancer Rates for All Subtypes

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Black-white patterns in subtype-specific breast cancer incidence rates differ for men and women
Frailty is an important predictor of worse outcome after traumatic spinal cord injury in patients <75 years of age

Frailty May Worsen Outcomes in Traumatic Spinal Cord Injury

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Frailty may predict poor postoperative outcomes, particularly in tSCI patients younger than age 75
Rural communities face greater severe maternal morbidity and mortality than urban communities

Severe Maternal Morbidity, Mortality Both Up in Rural Areas

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Clinical factors together with social determinants of health pose challenge for rural communities
Coprescription of benzodiazepines and opioid agonist treatment is associated with an increased risk for drug-related poisoning mortality in opioid-dependent individuals

Benzodiazepines With Opioid Agonist Tx May Up Mortality Risk

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Coprescription of z-drugs with OAT also linked to increased risk for drug-related poisoning mortality
Anastrozole is associated with a long-term reduction in breast cancer risk

SABCS: Anastrozole Tied to Lasting Reduction in Breast Cancer Risk

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Breast cancer risk significantly lower at median follow-up of 131 months; effect continued after treatment