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High-dosage chloroquine diphosphate has potential safety hazards when used as adjunctive therapy for patients hospitalized with severe COVID-19

Adding High-Dose Chloroquine Not Advised for Severe COVID-19

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High-dose versus low-dose group had higher lethality until day 13, more instances of QTc interval >500 ms
COVID-19 is associated with a high rate of pulmonary embolism

High Rate of Pulmonary Embolism Found for Patients With COVID-19

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Two studies demonstrate high rate of PE; 100 percent sensitivity for PE seen for D-dimer level > 2,660 µg/L
An estimated 45.4 percent of U.S. adults may have an increased risk for COVID-19 complications due to chronic conditions

45.4 Percent of U.S. Adults at Risk for Complications With COVID-19

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These adults may be at increased risk due to existing chronic conditions including CVD, diabetes, HTN
Upward income mobility is associated with lower perceived stress and fewer depressive symptoms but with higher rates of metabolic syndrome

Upward Income Mobility Tied to Worse Cardiometabolic Health

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Worse outcomes on all health indicators predicted by downward mobility
Job strain is associated with a 1.41-fold increase in the average risk for peripheral artery disease hospitalization

Job Strain Linked to Increase in Risk for PAD Hospitalization

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Estimates varied in magnitude but were consistent by sex, socioeconomic status, baseline smoking status
Social factors might be significant contributors to coexisting metabolic syndrome and osteoporosis in postmenopausal women

Social Inequality May Contribute to Poor Metabolic, Bone Health

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Risk for coexisting metabolic syndrome, osteoporosis up for postmenopausal women with low social status
Racial/ethnic discrimination is experienced by a large proportion of nonwhite residents in general surgery training

U.S. Surgical Residents Report Racial/Ethnic Discrimination Common

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Residents reported being mistaken for someone else of the same race or as a nonphysician
Pharmacologic treatment for type 2 diabetes increased from 2003 to 2016

Diabetes Medication Prescribing Increased 2003 to 2016

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However, authors say there is little evidence that doctors are tailoring treatment for patients
Recommendations have been developed for use of anesthesia during the COVID-19 pandemic

Recommendations Developed for Anesthesia Use During COVID-19

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Risk for postop complications lower with regional anesthesia; odds of aerosol generation up with general anesthesia
Acute respiratory distress syndrome due to COVID-19 is associated with neurologic features

Neurologic Features Tied to ARDS in Severe COVID-19 Described

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Unclear whether critical illness, medication, infection itself may cause encephalopathy, agitation, confusion