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The selective Hedgehog antagonist PF-04449913 seems safe and is tolerated in adults with myeloid malignancies

New Rx for Myeloid Malignancies Moves to Phase II Clinical Trials

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Phase I trial involving 47 patients identified maximum tolerated dose of 400 mg once daily
For patients with neural foraminal or lateral recess stenosis with unilateral leg neurogenic symptoms

No Lasting Value for Minimally Invasive Lumbar Laminotomy

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No differences or improvement in back or leg pain, ODI, neurogenic symptoms, SF-36 scores
The incidence of paradoxical adipose hyperplasia following cryolipolysis may be higher than previously described

Higher Incidence of Paradoxical Adipose Hyperplasia Reported

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Two case reports in single practice indicate incidence of 0.47 percent; higher than described previously
In a position statement published online July 20 in the Journal of Clinical Oncology

ASCO Calls for Cancer Trials to Include More Seniors

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Older adults react differently to treatment, oncology group notes
Between 1999 and 2013

Mortality, Hospital Stays, Costs All Down Among U.S. Seniors

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Researchers find steady improvement among Medicare enrollees from 1999 through 2013
Millions more Americans have affordable health insurance

Patients Report Improved Care Access, Better Health With ACA

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Gains seen in how many adults have insurance and a doctor, and say they are in better health
A longitudinal study that will track the personal and professional experiences of early-career pediatricians has been developed. The details are published online July 27 in Pediatrics.

Study Developed to Track Pediatricians’ Experiences

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Pediatricians enrolled in study that will track personal, professional experiences of early careers
The 2008 Hospital-Acquired Conditions Initiative payment changes for pressure ulcers have had a minimal effect

2008 Initiative Had Minimal Impact on Pressure Ulcer Charges

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Hospital-Acquired Conditions Initiative cut payment in 0.003 percent of discharges
From 2002 to 2012

Higher Health Costs for Diabetes Mainly Meds, Inpatient Care

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Individuals with diabetes had more than double the unadjusted mean direct expenditures over 10 years
Not all placebos are equally effective for knee osteoarthritis and some can trigger clinically relevant responses

Not All Placebos Are Equal in Knee Osteoarthritis

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Differential placebo effects can alter estimates of the relative efficacies of active treatments