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Survodutide Tied to Significant Improvement in Fatty Liver Disease

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Benefits seen without worsening of fibrosis over 48 weeks

Prolonged β-Lactam Antibiotic Infusions Aid Sepsis, Septic Shock Outcomes

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Lower risk seen for 90-day mortality and intensive care unit mortality

Preoxygenation With Noninvasive Ventilation Yields Lower Hypoxemia

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Hypoxemia occurred in fewer patients in noninvasive-ventilation group than in oxygen-mask group

Tirzepatide Beneficial for Resolution of MASH in Patients With MASH, Fibrosis

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More patients met criteria for resolution of MASH without worsening of fibrosis with 52 weeks of tirzepatide

ENDO: Novel Male Contraceptive Gel May Achieve Faster Sperm Suppression

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Gel is combination of segesterone acetate and testosterone

ENDO: Teprotumumab Shows Long-Term Efficacy for Thyroid Eye Disease

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Inflammatory and ophthalmic composite outcome improvements seen in 90 percent of patients at 72 weeks

ENDO: Early Menopause Tied to Heightened Risk for Breast, Ovarian Cancer

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Primary ovarian insufficiency also tied to higher risk for breast cancer

ASCO: Ivonescimab Improves Progression-Free Survival in EGFR+ Lung Cancer

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PFS benefit seen in most subgroups, including those whose disease progressed while receiving third-generation EGFR-TKIs

ASCO: Osimertinib Improves Progression-Free Survival in EGFR-Mutated Lung Cancer

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Significantly longer progression-free survival, but not overall survival, seen for osimertinib in unresectable EGFR-mutation NSCLC

ASCO: Neoadjuvant Ipilimumab + Nivolumab Ups Survival in Resectable Melanoma

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Neoadjuvant treatment followed by surgery results in longer event-free survival for resectable, macroscopic stage III melanoma