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For premenopausal women with estrogen receptor-positive

ASCO: Survival Up With Ribociclib in Advanced Breast Cancer

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OS longer for premenopausal patients receiving ribociclib in addition to endocrine therapy
Venetoclax-obinutuzumab is associated with longer progression-free survival than chlorambucil-obinutuzumab among patients with untreated chronic lymphocytic leukemia and coexisting conditions

ASCO: Combo Regimen Effective in CLL With Coexisting Conditions

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Progression-free survival longer with venetoclax-obinutuzumab versus chlorambucil-obinutuzumab
Maintenance therapy with olaparib is associated with improved progression-free survival in metastatic pancreatic cancer patients with a germline BRCA1 and/or BRCA2 mutation

ASCO: Olaparib Beats Placebo for BRCA-Related Pancreatic Cancer

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Progression-free survival significantly improved with olaparib versus placebo for metastatic disease
For frail and elderly patients with advanced gastroesophageal cancer

ASCO: Low-Dose Chemo Benefits Advanced Gastroesophageal Cancer

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Elderly, frail receiving 60 percent of oxaliplatin/capecitabine dose have noninferior PFS, less toxicity
Pembrolizumab is noninferior to chemotherapy for overall survival among patients with programmed death ligand 1

ASCO: Pembrolizumab Noninferior to Chemo in Advanced Gastric Cancer

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For patients with PD-L1 combined positive score of ≥10, pembrolizumab prolongs overall survival
Removal of low-density lipoproteins (LDL) by extracorporeal filtration during LDL-apheresis is associated with a large reduction in mean LDL in acute coronary syndrome patients treated with percutaneous coronary intervention

LDL Decreased With LDL-Apheresis in ACS Patients

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Significant reduction seen in mean LDL among patients with acute coronary syndrome treated with PCI
For patients with chronic obstructive pulmonary disease

High-Deductible Health Plans May Be Harmful for Patients With COPD

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Individuals with HDHP more likely to report forgoing care due to costs, cost-related nonadherence
From 2010 to 2017

Decrease in PM2.5-Related U.S. Mortality From 2010 to 2017

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During the same period, ozone-related mortality remained mainly unchanged
Compared with men

Women With COPD Have Worse QoL, Increased Symptom Burden

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Women are more likely to be symptomatic, have greater odds of frequent, severe acute exacerbations
A closed intensive care unit (ICU) model

Closed ICU Model May Reduce Hospital-Acquired Infections

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Decline seen in CLABSI, CAUTI, VAP rates; no change in C. diff infection, MRSA blood infection rates