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Ticagrelor plus aspirin compared with placebo plus aspirin is associated with a lower incidence of ischemic cardiovascular events but a higher incidence of major bleeding among patients with stable coronary artery disease and type 2 diabetes

Benefit, Harm Seen for Ticagrelor Plus Aspirin in Stable CAD With T2DM

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Incidence of ischemic cardiovascular events lower but major bleeding increased versus placebo plus aspirin
For patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease

Complete Revascularization Best for STEMI With Multivessel CAD

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Complete revascularization better than culprit lesion-only percutaneous coronary intervention
Changes in the harmonics of the radial pulse wave during menopause may reflect cardiovascular risk

Changes in Radial Pulse During Menopause May Reflect CV Risk

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Age and body mass index, but not menopause, have significant, independent effects on systolic BP
Delay in initiation of chemotherapy is associated with poorer overall survival for breast cancer

Delay in Time to Chemo Impacts Survival in Breast Cancer

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Time interval from diagnosis to surgery has largest impact on time from diagnosis to chemo initiation
For HIV-infected women receiving dolutegravir from the time of conception

Neural-Tube Defects Up for Offspring of Women on Dolutegravir

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Prevalence of neural-tube defects with dolutegravir higher than with other antiretroviral tx
A staging system of β-amyloid accumulation may be useful for monitoring patients throughout the course of Alzheimer disease

Novel PET Staging System May Help Monitor Alzheimer Disease

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Positron emission tomography used to track stages of β-amyloid accumulation in vivo
Athletes with attention-deficit/hyperactivity disorder with concussion seem to have longer recovery than controls

Recovery From Concussion Longer for Athletes With ADHD

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Athletes with ADHD had more symptoms at 24 to 48 hours, regardless of psychostimulant use
Greater physical activity and lower vascular risk are associated with slower β-amyloid-related cognitive decline in clinically normal older adults

Physical Activity Linked to Slower Aβ-Related Cognitive Decline

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Exercise, lower vascular risk independently attenuate negative link for Aβ burden, cognitive decline
Multiple sclerosis (MS) patients have an elevated cancer risk compared with non-MS controls

Increased Cancer Risk Seen in Multiple Sclerosis Patients

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Cancer risk up for MS patients versus non-MS controls, especially in respiratory, urinary, CNS organs
Patients undergoing partial knee replacement have a reduced risk for venous thromboembolism and opioid use in months 3 to 12 after surgery

VTE Risk Reduced With Partial Knee Replacement

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But risk for five-year revision higher for those undergoing partial versus total knee replacement