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ECG Metrics May Predict Cardiac Deaths in CKD Patients

Stronger as markers for cardiovascular death than for all-cause mortality or noncardiovascular death

FRIDAY, July 10, 2015 (HealthDay News) — Certain electrocardiographic (ECG) measures may improve prediction of cardiovascular death in patients with chronic kidney disease (CKD), according to research published online July 9 in the Journal of the American Society of Nephrology.

Rajat Deo, M.D., of the University of Pennsylvania in Philadelphia, and colleagues analyzed data for a prospective cohort of 3,939 participants with CKD to assess whether common ECG parameters are independent predictors of mortality risk.

The researchers found that ECG metrics were independent markers for risk of cardiovascular death, including PR interval ≥200 ms (hazard ratio [HR], 1.62; 95 percent confidence interval [CI], 1.19 to 2.19); QRS interval 100 to 119 ms (HR, 1.64; 95 percent CI, 1.20 to 2.25) and ≥120 ms (HR, 1.75; 95 percent CI, 1.17 to 2.62); corrected QT interval ≥450 ms in men or ≥460 ms in women (HR, 1.72; 95 percent CI, 1.19 to 2.49); and heart rate ≥90 beats per minute (HR, 2.35; 95 percent CI, 1.03 to 5.33). Most ECG metrics were stronger markers of risk for cardiovascular death than for noncardiovascular death or all-cause mortality. Adding these markers to a comprehensive model of cardiorenal risk factors significantly increased the C-statistic for cardiovascular death from 0.77 to 0.81.

“These data suggest common ECG metrics are independent risk factors for cardiovascular death and enhance the ability to predict death events in a population with CKD,” the authors write.

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