Home Critical Care Early Anticoagulation May Not Up Survival in Severe COVID-19

Early Anticoagulation May Not Up Survival in Severe COVID-19


Deprecated: mb_convert_encoding(): Handling HTML entities via mbstring is deprecated; use htmlspecialchars, htmlentities, or mb_encode_numericentity/mb_decode_numericentity instead in /var/www/html/ehealth-news.com/wp-content/plugins/healthday-hyperlink-stripper/healthday-hyperlink-stripper.php on line 16

Venous thromboembolism seen in 6.3 percent and major bleeding seen in 2.8 percent of critically ill COVID-19 patients

THURSDAY, Jan. 28, 2021 (HealthDay News) — Early therapeutic anticoagulation does not appear to affect survival among critically ill adults with COVID-19, according to a study published online Jan. 26 in the Annals of Internal Medicine.

Hanny Al-Samkari, M.D., from Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues evaluated the incidence of venous thromboembolism (VTE) and major bleeding in 3,239 critically ill adults with COVID-19 (67 hospitals; median age, 61 years; 64.5 percent men) and examined the effect of early therapeutic anticoagulation (within the first two days of intensive care unit [ICU] admission) on survival.

The researchers found that 204 patients (6.3 percent) developed VTE and 90 patients (2.8 percent) developed a major bleeding event. Male sex and higher D-dimer level on ICU admission were independent predictors of VTE. The analysis included 2,809 patients in the target trial emulation, with 11.9 percent receiving early therapeutic anticoagulation. During a median follow-up of 27 days, patients who received early therapeutic anticoagulation had a similar risk for death as those who did not (hazard ratio, 1.12; 95 percent confidence interval, 0.92 to 1.35).

“Our findings do not support early empirical use of therapeutic anticoagulation in critically ill patients with COVID-19,” the authors write. “These findings highlight the need for well-designed, adequately powered randomized clinical trials of therapeutic anticoagulation in critically ill patients with COVID-19.”

Copyright © 2020 HealthDay. All rights reserved.