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Tiotropium appears to be effective at improving lung function in patients with mild to moderate chronic obstructive pulmonary disease

Tiotropium Effective in Mild to Moderate COPD

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Daily inhaled dose tied to improvements in FEV1 compared to placebo
For patients with uncontrolled asthma despite treatment with long-acting beta-agonists and medium-to-high doses of inhaled glucocorticoids

Reduced Asthma Exacerbations Seen With Tezepelumab

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Reduction seen with three dose levels of tezepelumab regardless of blood eosinophil counts
Proposed budget cuts could seriously hamper efforts to address antimicrobial resistance

Budget Cuts Threaten Research on Antimicrobial Resistance

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Patient safety, international status of the U.S. as leader in combating AMR both at risk
Universal sequencing of a broad panel of cancer-related genes is associated with increased detection of potentially clinically significant heritable mutations

Universal Sequencing of Cancer Genes Ups Mutation Detection

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Increased detection of heritable mutations over the predicted yield of testing based on guidelines
Physicians should be aware of societal codes of conduct that affect family beliefs and behaviors regarding information disclosure to pediatric patients

Docs Should Be Aware of Family Beliefs Regarding Nondisclosure

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Evidence from Middle East literature suggests variability in practices, preferences of truth telling
Referring physicians have limited knowledge regarding indications for primary prevention implantable defibrillator use

Knowledge on Primary Prevention ICD Use Found Lacking

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Barriers for referral differ for internists, cardiologists, cardiology residents
For elderly patients treated with vitamin K antagonists for venous thromboembolism

CYP2C9 Variants Linked to Clinical Events in VTE

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Risk of any clinical event, death, non-major bleeding up for seniors treated with vitamin K antagonists
More research is needed to assess the role of vitamin D in the prevention of periprocedural myocardial injury

More Research Needed for Vitamin D’s Cardiac Effect in PCI

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Little effect on cardiac biomarker levels; significant effect on mean difference in CK-MB, hs-CRP
Non-Hispanic black and Hispanic children are less likely than non-Hispanic white children to receive antibiotics for viral acute respiratory tract infection in the pediatric emergency department

Racial Variation in Antibiotic Prescribing for Viral ARTI

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Non-Hispanic black, Hispanic children less likely than non-Hispanic white children to receive antibiotics
A computer-based alert system with a Geneva Risk Score calculation tool in the electronic patient chart does not improve appropriate thromboprophylaxis in patients admitted to general medical wards

Electronic Alert Doesn’t Up Appropriate Thromboprophylaxis

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Patients with no score or inconsistent score result less often had appropriate thromboprophylaxis