Increased Flexibility Seen in Preapproval Evidence for New Drugs
Twenty-eight percent of trials used historical, external, or other control; nearly half used surrogate measure as a primary end point
Albuterol Plus Budesonide Cuts Exacerbations in Asthma
Risk for severe exacerbations significantly lower with as-needed fixed higher-dose combination treatment versus albuterol alone
Emphysema Prevalence Higher in Black Adults
Spirometry measures predicted based on race-specific equations may result in underrecognition of lung disease in Black adults, authors say
Coronary Heart Disease Risk Higher With COPD
However, emphysema score, lung function, exacerbation frequency, and hypoxemia do not predict coronary stenosis or calcium score >100
Cessation Program in Cancer Clinics May Reach More Tobacco Smokers
Low-burden, point-of-care program may increase access to and impact of treatment to assist tobacco cessation
Slight Increase Reported in Lung Cancer, Brain Tumors With Wildfire Exposure
Individuals exposed to wildfire within 50 km of residential locations in past 10 years had slightly higher incidence
Previous Myocardial Injury Tied to Worse COVID-19 Outcomes
Significant but weaker associations with selected adverse outcomes seen for preexisting hypertension, diabetes, and ischemic heart disease
Number of Mesothelioma Deaths Up Among Women From 1999 to 2020
However, age-adjusted death rate per 1 million women decreased significantly, from 4.83 to 4.15 from 1999 to 2020
Lack of Asthma Control More Likely With COVID-19-Related Anxiety
Second study shows most parents of children with food allergy report unchanged or decreased food allergy-specific anxiety during pandemic
Neuropsychiatric Sequelae Similar for Severe COVID-19, SARI
Neuropsychiatric sequelae are comparable for survivors of COVID-19 hospitalization, other severe acute respiratory infections