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Increased Flexibility Seen in Preapproval Evidence for New Drugs

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Twenty-eight percent of trials used historical, external, or other control; nearly half used surrogate measure as a primary end point

B 5/18 -- Dirty Air Killed 9 Million People Worldwide in 2019

Albuterol Plus Budesonide Cuts Exacerbations in Asthma

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Risk for severe exacerbations significantly lower with as-needed fixed higher-dose combination treatment versus albuterol alone

Black Seniors With GI Malignancy More Likely to Be Frail

Emphysema Prevalence Higher in Black Adults

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Spirometry measures predicted based on race-specific equations may result in underrecognition of lung disease in Black adults, authors say

Carrying out a description of the radiographs of a patient with COPD

Coronary Heart Disease Risk Higher With COPD

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However, emphysema score, lung function, exacerbation frequency, and hypoxemia do not predict coronary stenosis or calcium score >100

FDA Proposes Ban on Menthol Cigarettes

Cessation Program in Cancer Clinics May Reach More Tobacco Smokers

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Low-burden, point-of-care program may increase access to and impact of treatment to assist tobacco cessation

5/16 -- Wildfire Survivors Could Face Higher Cancer Risk

Slight Increase Reported in Lung Cancer, Brain Tumors With Wildfire Exposure

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Individuals exposed to wildfire within 50 km of residential locations in past 10 years had slightly higher incidence

Accelerated Trajectory of CV Risk Predicts Dementia Risk

Previous Myocardial Injury Tied to Worse COVID-19 Outcomes

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Significant but weaker associations with selected adverse outcomes seen for preexisting hypertension, diabetes, and ischemic heart disease

Human Respiratory System Anatomy

Number of Mesothelioma Deaths Up Among Women From 1999 to 2020

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However, age-adjusted death rate per 1 million women decreased significantly, from 4.83 to 4.15 from 1999 to 2020

Asthma in Adults May Raise Risk for Subsequent Obesity

Lack of Asthma Control More Likely With COVID-19-Related Anxiety

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Second study shows most parents of children with food allergy report unchanged or decreased food allergy-specific anxiety during pandemic

ADHD Tied to Fourfold Higher Likelihood of Having Anxiety Disorder

Neuropsychiatric Sequelae Similar for Severe COVID-19, SARI

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Neuropsychiatric sequelae are comparable for survivors of COVID-19 hospitalization, other severe acute respiratory infections