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Women at both extremes of the weight spectrum have low mean serum allopregnanolone

Mean Serum Allopregnanolone Low Across Weight Extremes

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Also tied to increased depression and anxiety severity, independent of body mass index
The combination of environmental enrichment and magnesium-L-threonate is more effective than either treatment alone for improving cognition and spatial memory in a mouse model of Alzheimer's disease

Magnesium Boosts Environmental Enrichment in Alzheimer’s

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Combination of EE, magnesium-L-threonate more effective than either treatment alone in mouse model
Older adults report feeling confident that they know how to avoid drug interactions despite only 35 percent having spoken to someone about it in the past year

Many Seniors Have Not Discussed Avoiding Drug Interactions

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69 percent of patients see multiple doctors, 21 percent use multiple pharmacies, complicating issue
The Value-Based Payment Modifier is not associated with performance differences between practices serving higher-risk and lower-risk patients

Value-Based Payment Modifier Not Tied to Practice Performance

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Performance differences between practices narrowed after adjustment for patient characteristics
Clinician denial of some types of tests requested by patients is associated with worse patient satisfaction with the clinician

Clinician Denial of Patient Requests Impacts Satisfaction

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Worse satisfaction in association with denial of request for referral, pain meds, other meds, lab tests
For reversal of opioid overdose

Similar Efficacy for Intranasal, Intramuscular Naloxone

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Similar efficacy for higher-concentration intranasal naloxone, IM naloxone administered at same dose
Heart rate variability and specific inflammatory biomarkers can differentiate major depressive disorder from depression in bipolar disorder

Simple ECG May Help Distinguish MDD From Bipolar Depression

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Higher low-frequency heart rate variability, lower levels of IL-10 and MCP-1 for major depression
Coffee consumption seems safe and is associated with reduced risk for various health outcomes

Coffee Consumption Appears to Provide More Benefit Than Harm

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Largest relative reduction in health outcomes seen with intake of three to four cups/day versus none
In a policy statement published online Nov. 27 in Pediatrics

Recommendations Developed for Addressing Child Trafficking

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Guidelines provided for prevention of trafficking, identifying victims, intervening appropriately
AVATAR therapy

AVATAR Therapy Promising for Auditory Hallucinations

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Reduction in PSYRATS-AH total score significantly greater with AVATAR tx versus supportive counseling