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A 14-day course of an Fc receptor-nonbinding anti-CD3 monoclonal antibody

ADA: Teplizumab Can Delay T1DM Progression in Those at Risk

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Median time to type 1 diabetes diagnosis 48.4 months with teplizumab and 24.4 months with placebo
Persistently high fat mass during adolescence is associated with greater arterial stiffness

Obesity During Teen Years Tied to Stiffening of Arteries

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This adverse effect is further aggravated by an unfavorable metabolic profile
For cancer drugs ultimately approved by the U.S. Food and Drug Administration

Approving Children’s Cancer Drugs Takes 6.5 Years Longer

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Gap reflects time from first clinical trial in humans to the first trial in children
Early-life exposure to fine particulate matter is associated with a reduction in fundamental cognitive abilities

Exposure to Air Pollution May Impact Children’s Cognitive Abilities

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Deficits seen in working memory, executive attention after prenatal, early childhood exposure
Many health care providers in the United Kingdom have little direct experience with online feedback

Most Providers Unaware of Online Feedback About Themselves

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Providers do not encourage patient reviews and often view such feedback as having limited value
Valproic acid and topiramate are confirmed teratogens

Study Confirms Teratogenicity of Valproic Acid, Topiramate

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Eight specific types of major congenital malformations associated with prenatal exposure to valproic acid
Metagenomic next-generation sequencing of cerebrospinal fluid obtained from patients with meningitis or encephalitis can improve diagnosis of neurologic infections

Next-Gen Sequencing of CSF Improves Diagnosis of CNS Infections

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Eight of 13 diagnoses made solely by metagenomic NGS had likely clinical effect, seven guided treatment
Engaging in higher levels of physical activity in childhood is associated with better cardiovascular health indicators

Higher Levels of Exercise in Childhood Improve Heart Health

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Better cardiovascular health indicators seen with engaging in higher levels of physical activity
Undervaccinated and unvaccinated children are at increased risk for pertussis

Pertussis Risk Up for Undervaccinated, Unvaccinated Children

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However, most pertussis cases occur among vaccinated children further away from last DTaP dose
Children with community-acquired pneumonia often receive diagnostic testing and antibiotic therapy despite publication of guidelines against their routine use in 2011

Diagnostic Testing, Antibiotics Overused in Pediatric CAP

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Chest radiography ordered in 43 percent, antibiotics prescribed in 73.9 percent of community-acquired pneumonia visits