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Iressa (gefitinib) has been approved by the U.S. Food and Drug Administration to treat patients with metastatic non-small-cell lung cancer with a specific genetic mutation (epidermal growth factor receptor [EGFR]). A just-approved companion diagnostic test can identify patients who could benefit from this new use.

FDA Approves Iressa for EGFR+ Metastatic Lung Cancer

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New companion diagnostic kit can identify candidates
Lower levels of circulating myeloid dendritic cell subtype 2 in children who live on farms may contribute to a protective effect against asthma

Farm-Related Immunoregulation Tied to Dendritic Cell Subset

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Lower levels of circulating myeloid dendritic cell subtype 2 in children who live on farms
Specific biomarkers correlate with cardiovascular dysfunction and all-cause mortality among HIV-infected individuals

Specific Biomarkers ID Cardiac Dysfunction, Mortality Risk in HIV

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ST2 and GDF-15 linked to cardiovascular dysfunction and all-cause mortality in HIV-infected
An IGF2 variant (c.191C→A

IGF2 Variant Affects Prenatal and Postnatal Growth

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Severe growth restriction for family members who inherit the variant through paternal transmission
Unique presentation of herpes simplex virus infection in pregnancy can be misdiagnosed as premature rupture of membranes

Herpes Simplex Virus Can Mimic Premature Rupture of Membranes

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Case vignette describes woman with leakage of clear fluid, despite normal amniotic fluid volume
After the mysterious deaths of three German variegated squirrel breeders

Exotic Squirrels Transmit Deadly Virus to Breeders in Germany

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Breeders diagnosed with encephalitis and died within two to four months of symptom onset
People living in 94 counties spread across the lower Mississippi Delta region

Pockets of U.S. Have Excessive Colorectal Cancer Mortality

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Areas include parts of the Mississippi Delta, Appalachia, and eastern Virginia
Certain genetic mutations may be correlated with response to therapy and prognosis in aplastic anemia

Genetic Mutations May Impact Outcomes in Aplastic Anemia

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Genetic evaluation may help predict prognosis in aplastic anemia
For many cancers

Mortality Rates Declining for Many Cancers

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Rates predicted to meet Healthy People 2020 targets for breast, lung, prostate cancers
Weight loss of 5 percent or more

Weight Loss + Vitamin D3 Cuts IL-6 in Postmenopausal Women

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Reduction in inflammatory biomarkers among women with BMI >25 kg/m², low serum 25(OH)D