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Genetic analysis can improve diagnosis and management of intellectual developmental disorder and unexplained metabolic abnormalities

Genetic Analysis Offers Options for Some Developmental Delay

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Exome sequencing led to better treatments in four of 10 cases studied
A predictive model for chemotherapy toxicity has been validated for older patients with solid tumors

Chemotherapy Toxicity Predictive Model Validated

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Predictive model for older adults with cancer validated in independent cohort of 250 individuals
Benzyl butyl phthalate regulates the mesenchymal stem cell toward adipogenesis by inducing epigenetic stress

Plastics Chemical BBP Exposure May ‘Program’ Obesity

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BBP exposure enhances lipid accumulation and adipogenesis in dose-dependent manner
Average leucocyte telomere length and the abundance of short telomeres (percent LTL <3 kb) are not significant independent determinants of subclinical atherosclerosis

Telomere Length Not Significantly Associated With Atherosclerosis

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LTL, abundance of short telomeres are not independent determinants of atherosclerosis
Obese adolescents may have lower levels of the hormone spexin than normal-weight adolescents

Low Levels of Hormone Associated With Teen Obesity

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Teens with the lowest levels of spexin more than five times as likely to be obese
Although overall colorectal cancer rates are declining

DDW: Incidence of Colorectal Cancer Up in Younger People

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Incidence up 11.4 percent in 10 years among Americans younger than 50
Air pollution can worsen cardiovascular disease risk factors

Study Upholds Link Between Air Pollution and Higher CVD Risk

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Three months of exposure associated with higher cholesterol levels, especially for those with diabetes
AMPK activation by metformin is associated with inhibition of interstitial fibrosis and suppression of transforming growth factor β-1

Metformin Combats Adipose Tissue Expansion Via AMPK

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AMPK activation is linked to inhibition of interstitial fibrosis, suppression of TGF-β1
Fecal microbiota transplantation appears to alleviate symptoms in treatment-resistant ulcerative colitis patients

DDW: Fecal Transplant Might Help Relieve Symptoms of Colitis

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Fecal microbiota transplantation found to improve symptoms in treatment-resistant patients
Many patients with advanced cancer lack basic information about their prognosis or treatment

Many Advanced Cancer Patients Lack Info About Their Disease

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Just one in 20 terminally ill people understood their prognosis, researchers say