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Investigators describe a strategy for development of a broad-spectrum anti-viral agent. Their research was published online May 19 in Nature Communications.

ISG15 Deficiency Linked to Antiviral Immunity in Humans

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In contrast to Isg15-deficient mice, deficient patients have no enhanced susceptibility to viruses
Uninsurance rates have decreased since the introduction of the Affordable Care Act

Remaining Uninsured May Be Difficult to Reach Via ACA

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Reaching the remaining uninsured may be difficult due to lack of Medicaid expansion on the state level
The first case of a patient infected with a superbug resistant to a last-resort antibiotic has been documented in the United States. The report was published online May 26 in Antimicrobial Agents and Chemotherapy.

U.S. Has First Documented Case of Superbug Resistant to Colistin

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Pennsylvania woman infected with E. coli that carried a gene for resistance against last-resort antibiotic
New research

Zika Infects, Replicates in Immune Cells From Placenta

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Researchers find virus can replicate in immune cells from the placenta without killing them
The risk of major adverse cardiovascular events is increased with renal function decline

Renal Function Decline Linked to Major Adverse CV Events

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Renal function decline is independent factor for cardiovascular risk in patients with type 2 diabetes
Some leading insect and infectious-disease experts think health officials in the United States are overreacting to the threat posed by the Zika virus this summer.

How Much of a Threat Will Zika Be to the United States?

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Experts say Gulf Coast states face risk, but most other states probably don't
Women who carry common gene variants linked to breast cancer can still reduce risk of the disease by following a healthy lifestyle

Genetic Breast Cancer Risk Can Be Mediated by Healthy Lifestyle

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Key lifestyle factors include maintaining a healthy weight, not smoking, limiting alcohol, no HRT
Prolactin receptor signaling plays a role in expansion of maternal β-cells during pregnancy

Prolactin Receptor Signaling Linked to Expansion of β-Cells

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Molecular roles for PRLR signaling in expansion of maternal β-cells during pregnancy
Women with atrial fibrillation may be at an increased risk of developing cancer

Atrial Fibrillation Linked to Cancer Risk in Women

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Women with new-onset AF show elevated cancer risk beyond one year of AF diagnosis
Researchers have identified immune genes that may affect mortality in patients with glioblastoma multiforme

Eight Immune Genes Identified As Playing a Role in Glioblastoma

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Discovery might eventually lead to better treatment for glioblastoma multiforme