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Tumor cell-intrinsic metabolic factors may contribute to anti-programmed death 1 (PD-1)/PD-L1 treatment resistance in renal cell carcinoma

Metabolic Factors May Contribute to Tx Resistance in Renal Cancer

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Genes involved in metabolic and solute transport function linked to treatment failure in PD-L1+ RCC
The Amish environment seems to provide protection against asthma and allergic sensitization

Amish Farm Environment May Protect Children From Asthma

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Amish, Hutterite children have profound differences in proportions, phenotypes, functions of immune cells
Prolonged detection of Zika virus RNA has been documented in five pregnant women

Prolonged Detection of Zika RNA Reported in Pregnant Women

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Zika virus RNA detected up to 46 days after symptom onset; 53 days after exposure in five women
Patients with impaired glucose tolerance face an increased risk of mortality

Mortality Up With Impaired Glucose Tolerance

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Much of the increase associated with impaired glucose tolerance due to progression to diabetes
Women with vaginal mesh with complications have a significantly increased proinflammatory response

Proinflammatory Response in Women With Vaginal Mesh

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Significantly higher M1/M2 cytokines, chemokines, MMP-9 and -2 in women with mesh-vagina explants
A third dose of measles-mumps-rubella (MMR) vaccine is recommended in cases of mumps outbreak in which transmission is sustained despite high two-dose MMR coverage

Third Dose of MMR Vaccine Can Help Control Mumps Outbreaks

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CDC advised third dose in recent outbreak with transmission despite high two-dose coverage
Topical application of BRAF inhibitors may accelerate healing of skin wounds

BRAF Inhibitors May Accelerate Wound Healing

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Topical application with vemurafenib accelerated wound healing via paradoxical MAPK activation
Targeted therapies that do not contain erlotinib can be beneficial for patients with KRAS-mutated advanced non-small-cell lung cancer

Targeted Therapies Beneficial in KRAS-Mutated NSCLC

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Improved progression-free survival for patients treated with therapy not containing erlotinib
Two novel loci have been identified that are associated with insulin sensitivity

Study IDs Two Novel Loci Linked to Insulin Sensitivity

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Associations for BCL2 and FAM19A2 were independent of known cardiometabolic loci
Sickle cell trait is not associated with a higher risk of death than absence of the trait

Sickle Cell Trait Doesn’t Up Mortality Risk in U.S. Soldiers

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However, SC trait was linked with significantly higher risk of exertional rhabdomyolysis