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A distinctive phenotype of congenital Zika syndrome has been described in a review published online Nov. 3 in JAMA Pediatrics.

Review Identifies Features of Congenital Zika Infection

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Five factors identified as unique to Zika, including severe microcephaly with partially collapsed skull
Psoriasis patients have increased global arterial inflammation and subcutaneous inflammation

Increased Global, Subcutaneous Inflammation in Psoriasis

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Increased 18F-fluorodeoxyglucose uptake values indicate arterial and subcutaneous inflammation
Patients with melanoma treated with a combination of ipilimumab and nivolumab may be at risk for a potentially fatal T-cell-driven drug reaction

Myocarditis ID’d With Ipilimumab + Nivolumab in Melanoma

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Case report describes two patients who developed fatal T-cell-driven drug reaction
Healthy participants receiving the orally administered reversible fatty acid amide hydrolase inhibitor

Severe Neurologic Disorder With Administration of BIA 10-2474

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Phase 1 study involving healthy volunteers results in severe neurologic disorder, with one brain death
For patients without diabetes

Incidence of Statin-Associated T2DM Relatively Low

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Diabetogenic impact of statins increases as fasting plasma glucose, triglycerides, and BMI increase
As children age

Impact of HbA1c, BMI Changes on Lipids Varies As Children Age

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HbA1c, BMI have modest impact on LDL and non-HDL cholesterol levels, but not on HDL
For patients with papillary thyroid cancer

Patient Age Linked to Survival in Papillary Thyroid Cancer

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Linear reduction in cancer-specific survival with increasing age, with no evidence of a cut point
A case of acute hepatitis tied to excessive energy drink consumption is detailed in a report published online Nov. 1 in BMJ Case Reports.

Acute Hepatitis Described With Excessive Energy Drink Intake

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Patient reported drinking four to five energy drinks per day for three weeks before admission
For HIV-infected pregnant women

Maternal, Neonatal Adverse Events Up With Antenatal ART

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But antiretroviral therapy also linked to significantly lower rates of early HIV transmission

October 2016 Briefing – Pathology

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Here are what the editors at HealthDay consider to be the most important developments in Pathology for October 2016. This roundup includes the latest...