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Methodological concerns have limited the analysis of saliva-based biomarkers for oral squamous cell carcinoma

Review: Methodological Limitations for OSCC Biomarkers

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Limitations include lack of methodological criteria within studies, lack of consensus on marker choices
Functionally characterized variants in hepatocyte nuclear factor-1a genes

Functionally ID’d Variants in HNF1A Linked to Diabetes Risk

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Functionally characterized variants that reduce HNF-1A transcriptional activity strongly linked to diabetes
Variants in genes encoding proprotein convertase subtilisin-kexin type 9 and 3-hydroxy-3-methylglutarylcoenzyme A reductase are associated with almost equivalent effects on the risk of cardiovascular events and diabetes per unit decrease in low-density lipoprotein cholesterol level

Similar Effects for PCSK9, HMGCR Variant-Mediated Lower LDL

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Almost equivalent effects on cardiovascular events, diabetes per unit decrease in LDL-cholesterol level
Cerebrospinal fluid real-time quaking-induced conversion has high diagnostic specificity and sensitivity for prion diseases

CSF RT-QuIC Has High Diagnostic Specificity, Sensitivity for Prions

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Diagnostic specificity, sensitivity of 98.5, 92 percent, respectively, in blinded retrospective analysis
Alcohol intake is associated with increased risk of melanoma

Alcohol Intake Linked to Increase in Risk of Melanoma

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Correlation stronger for melanoma in relatively UV-spared sites versus UV-exposed sites
Use of a vaginal ring containing dapivirine is efficacious for prevention of HIV-1 infection

Dapivirine Vaginal Ring Can Help Prevent HIV-1 Infection

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Findings among healthy, sexually active women from South Africa and Uganda
The number of people in families having problems paying medical bills fell by nearly 13 million from 2011 through the first six months of 2016

CDC: Fewer U.S. Families Struggling to Pay Medical Bills

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More Americans are experiencing relief with medical bills, but gaps remain
A significant number of patients with HIV have strains of the virus that are resistant to both older and newer drugs

More HIV Patients Exhibiting Multidrug Resistance

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Patients resistant to older medications also have problems with newer drugs

November 2016 Briefing – Pathology

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Here are what the editors at HealthDay consider to be the most important developments in Pathology for November 2016. This roundup includes the latest...
Primary care providers order significantly more food allergen panels and generate higher costs per patient than allergists

PCPs Order More Food Allergen Panels Than Allergists

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Also order more tests for uncommon causes of food allergy and generate higher costs